{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:47:57Z","timestamp":1784958477430,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570976"],"award-info":[{"award-number":["31570976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prevention of fragility fractures is one of the public health priorities worldwide, whilst the incidence of osteoporotic vertebral compression fractures (OVCF) continues to rise and lacks the corresponding accurate prediction model. This study aimed to screen potential causes and risk factors for primary non\u2010traumatic osteoporotic vertebral compression fractures (NTOVCF) in the elderly by characterizing a patient population with NTOVCF and comparing it with a population of osteoporotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2013 and January 2022, 208 elderly patients with unequivocal evidence of bone fragility manifested as painful NTOVCF were enrolled, and compared with 220 patients with osteoporosis and no fractures. The demographic data, bone turnover markers, blood routine, serum biochemical values, and radiological findings were investigated. Differences between the fracture and non\u2010fracture groups were analyzed, and variables significant in univariate analysis and correlation analysis were included in the logistic analysis to build the risk prediction model for osteoporotic vertebral fractures. Univariate analysis using student's <jats:italic>t<\/jats:italic>\u2010tests for continuous variables or a chi\u2010squared test for categorical variables was conducted to identify risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were revealed regarding age, gender, BMI, smoking, alcohol consumption, blood glucose, propeptide of type I procollagen (P1NP), and N\u2010terminal middle segment osteocalcin (N\u2010MID) (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Parathyroid Hormone (PTH), 25(OH)D, serum albumin (ALB), hemoglobin (HB), bone mineral density (BMD), and cross\u2010sectional area (CSA) of the paraspinal muscle in the fracture group were significantly lower than those in the control group; however, b\u2010C\u2010terminal telopeptide of type I collagen (\u03b2\u2010CTX), total cholesterol (TC), high\u2010density lipoprotein cholesterol (HDL\u2010C), non\u2010prostatic acid phosphatase (NACP), and fatty degeneration ratio (FDR) were significantly higher than those in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Logistic regression analysis showed that ALB, HB, CSA, and BMD were negatively correlated with NTOVCF, while \u03b2\u2010CTX, HDL\u2010C, NACP, and FDR were positively correlated with NTOVCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased physical activity, anemia, hypoproteinemia, imbalances in bone metabolism, abnormal lipid metabolism, and degenerative and decreased muscle mass, were all risk factors for OVCF in the elderly, spontaneous fractures may be the consequence of cumulative declines in multiple physiological systems over the lifespan. Based on this risk model, timely detection of patients with high OVCF risk and implementation of targeted preventive measures is expected to improve the effect of fracture prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13531","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T09:20:33Z","timestamp":1664356833000},"page":"2925-2938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Study on Risk Factors of Primary Non\u2010traumatic <scp>OVCF<\/scp> in Chinese Elderly and a Novel Prediction Model"],"prefix":"10.1111","volume":"14","author":[{"given":"Zhenxing","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Spine Surgery The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Orthopedics and Traumatology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou 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The Seventh Affiliated Hospital of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Kiang Wu Hospital  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Guangzhou First People's Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Hoi","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Prince of Wales Hospital, The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-1674","authenticated-orcid":false,"given":"Bailing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery The 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