{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:16:35Z","timestamp":1779297395244,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital insensitivity to pain with anhidrosis (CIPA) with Charcot arthropathy is a rare combination in orthopaedic clinical practice. The experience dealing with such patients is limited. Here with this case of approximately 10\u2009years follow\u2010up, we wish to shed light on the choices of strategies of surgeries and alerting clinicians with post\u2010surgery complications. The possible underlying reasons for the recurrent Charcot arthropathies as well as strategies for peri\u2010operative management for such surgical cases are also discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>The patient underwent a surgery to correct her severe kyphosis caused by CIPA\u2010related Charcot spine. Multiple post\u2010surgery complications occurred during her follow\u2010up, including hardware migration, adjacent segment disease (ASD), and loosening pedicle screws. Five revision surgeries were conducted consequently. From the limited experience on the management of CIPA\u2010related Charcot spine, surgical correction is still the first\u2010line treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Of all the 16 cases reviewed (including our case), loosening pedicle screws, hardware migration, and ASDs are the common post\u2010surgery complications. Large\u2010scale removal of damaged vertebrae and subsequent reconstruction are not recommended, which might increase the risk of hardware migration. A 360\u00b0 long\u2010segment fusion might be of help to reduce the risk of ASDs. In the meantime, comprehensive management including careful nursing, proper rehabilitation exercises, and treatments targeting bone mineral metabolism is also critical.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13746","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:31:37Z","timestamp":1683538297000},"page":"1904-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From the Destruction of Two Lumbar Segments to Thoracic\u2010Lumbar\u2010Pelvic Fusion: A Case Caused by Congenital Insensitivity to Pain with Anhidrosis and Literature Review"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-7574","authenticated-orcid":false,"given":"Yuhao","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1224"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-017-0814-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.e237"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.11.024"},{"issue":"20","key":"e_1_2_8_6_1","first-page":"3988","article-title":"360\u00b0 fusion for Charcot spine caused by congenital insensitivity to pain with anhidrosis","volume":"126","author":"Bin F","year":"2013","journal-title":"Chin Med J (Engl) 2013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90091-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066863"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.35B3.399"},{"key":"e_1_2_8_10_1","first-page":"650","article-title":"A case of congenital insensitivity to pain with destructive arthropathies of the limbs and spine. 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