{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:04:16Z","timestamp":1793667856856,"version":"4.5.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>At present, the influence of Modic changes (MCs) on postoperative fusion rate of lumbar interbody fusion (LIF) is mainly focused on the medium\u2010 and long\u2010term fusion rate, while the short\u2010term fusion rate has not been reported. The aim of this study was to compare the short\u2010term fusion rate of lumbar degenerative disease patients with and without MCs after single level transforaminal lumbar interbody fusion (TLIF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective and matched\u2010pair case control study, we included 100 patients who underwent TLIF from January 2017 to January 2020 and had at least two follow\u2010up visits over a two\u2010year period. Fifty patients with MCs (MCs group) were matched with 50 patients without MCs (non MCs group) for age, sex, surgical level, diagnosis, operative time, and intraoperative blood loss. We collected the X\u2010ray and computed tomography (CT) data of patients from 3\u2009months to 2\u2009years after the operation to assess bony fusion and the cage union ratio. According to the type of cage, the MCs group was further divided into the nano\u2010hydroxyapatite\/polyamide 66 (n\u2010HA\/PA66) group and polyetheretherketone (PEEK) group, and the fusion performance between the two groups was compared. Finally, age, sex, body mass index (BMI), smoking and cage type were included in the logistic regression model for risk factor analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The bony fusion rates in the MCs group at 3\u2009months, 6\u2009months, 1\u2009year and 2\u2009years after surgery were significantly lower than those in the non MCs group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) (23.8% <jats:italic>vs<\/jats:italic> 62.5%, 52.6% <jats:italic>vs<\/jats:italic> 78.9%, 61.1% <jats:italic>vs<\/jats:italic> 83.3%, 74.0% <jats:italic>vs<\/jats:italic> 90.0%). The average coronal cage union ratios of the upper and lower endplates in the MCs group were significantly lower than those in the non MCs group (54.3%\u2009\u00b1\u200917.5% <jats:italic>vs<\/jats:italic> 75.0%\u2009\u00b1\u200917.2%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; 73.3%\u2009\u00b1\u200912.0% <jats:italic>vs<\/jats:italic> 84.9%\u2009\u00b1\u20098.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Similarly, analogous results were obtained by comparing the MCs and non MCs groups' three\u2010dimensional CT sagittal plane images (62.5%\u2009\u00b1\u200916.5% <jats:italic>vs<\/jats:italic> 76.1%\u2009\u00b1\u200912.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; 67.0%\u2009\u00b1\u200913.9% <jats:italic>vs<\/jats:italic> 79.8%\u2009\u00b1\u200911.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Short\u2010term fusion rates were lower in the MCs group than in the non MCs group. The coronal and sagittal cage union ratio in the MCs group was lower than that in the non MCs group. The fusion performance of n\u2010HA\/PA66 and PEEK cages in the MCs group was comparable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13795","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T09:09:26Z","timestamp":1689239366000},"page":"2309-2317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does Preoperative Modic Changes Influence the Short\u2010term Fusion Rate of Single Level Transforaminal Lumbar Interbody Fusion?\u2014a Matched\u2010pair Case Control Study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0216-1129","authenticated-orcid":false,"given":"Yang","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-3323","authenticated-orcid":false,"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-0740","authenticated-orcid":false,"given":"Yueming","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Orthopaedic Research Institute West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.1.3336678"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.1.3289089"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.10.070"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2017.11.4.594"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.09.060"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160915"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.150258"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.14245\/kjs.2014.11.4.221"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2009.46.4.322"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.21.05386-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2020.04.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181918aae"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.13593"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181c4baf5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.ST.15.00003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S338027"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.6.1043"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-013-2948-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003313"},{"key":"e_1_2_10_22_1","article-title":"Risk factors for subsidence following anterior lumbar interbody fusion. 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