{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:15:39Z","timestamp":1793855739696,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1102000"],"award-info":[{"award-number":["2016YFC1102000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1102004"],"award-info":[{"award-number":["2016YFC1102004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The three\u2010dimensional printing titanium (3DPT) cage with excellent biomechanical properties and osseointegration capabilities has been initially used in spinal fusion, while the polyetheretherketone (PEEK) cage, a bioinert material device, has been a widely used for decades with relatively excellent clinical outcomes. This study was performed to investigate the early radiographic and clinical outcomes of 3DPT cage versus PEEK cage in patients undergoing anterior cervical discectomy and fusion (ACDF) and transforaminal lumbar interbody fusion (TLIF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective controlled trial, from December 2019 to June 2022, included patients undergoing ACDF and TLIF with 3DPT cages and compared them to patients using PEEK cages for treating spinal degenerative disorders. The outcome measures included radiographic parameters (intervertebral height [IH], subsidence, fusion status, and bone\u2010cage interface contact) and clinical outcomes (Japanese Orthopaedic Association [JOA], Neck Disability Index [NDI], Oswestry Disability Index [ODI], Short Form 12\u2010Item Survey [SF\u201012], Visual Analog Scale [VAS], and Odom's criteria). Student's independent samples t test and Pearson's chi\u2010square test were used to compare the outcome measures between the two groups before surgery and at 1\u2009week, 3 and 6\u2009months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the patients undergoing ACDF, the 3DPT (18 patients\/[26 segments]) and PEEK groups (18 patients\/[26 segments]) had similar fusion rates at 3\u2009months and 6\u2009months follow\u2010up (3\u2009months: 96.2% <jats:italic>vs.<\/jats:italic> 83.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.182; 6\u2009months: 100% vs. 91.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.225). The subsidence in the 3DPT group was significantly lower than that in the PEEK group (3\u2009months: 0.4\u2009\u00b1\u20090.2\u2009mm vs. 0.9\u2009\u00b1\u20090.7\u2009mm <jats:italic>p<\/jats:italic>\u2009=\u20090.004; 6\u2009months: 0.7\u2009\u00b1\u20090.3\u2009mm vs. 1.5\u2009\u00b1\u20090.8\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). 3DPT and PEEK cage all achieved sufficient contact with the cervical endplates. For the patients undergoing TLIF, the 3DPT (20 patients\/[26 segments]) and PEEK groups (20 patients\/[24 segments]) had no statistical difference in fusion rate (3\u2009months: 84.6% vs. 58.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.059; 6\u2009months: 92.3% vs<jats:italic>.<\/jats:italic> 75%, <jats:italic>p<\/jats:italic>\u2009=\u20090.132). The subsidence was lower than that in the PEEK group without significantly difference (3\u2009months: 0.9\u2009\u00b1\u20090.7\u2009mm <jats:italic>vs.<\/jats:italic>1.2\u2009\u00b1\u20090.9\u2009mm <jats:italic>p<\/jats:italic>\u2009=\u20090.136; 6\u2009months: 1.6\u2009\u00b1\u20091.0\u2009mm vs. 2.0\u2009\u00b1\u20091.0\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.200). At the 3\u2010month follow\u2010up, the bone\u2010cage interface contact of the 3DPT cage was significantly better than that of the PEEK cage (poor contact: 15.4% vs<jats:italic>.<\/jats:italic> 75%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The values of UAR were higher in the 3DPT group than in the PEEK group during the follow\u2010up in cervical and lumbar fusion, there were more statistical differences in lumbar fusion. There were no significant differences in the clinical assessment between 3DPT or PEEK cage in spinal fusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 3DPT cage and PEEK cage can achieve excellent clinical outcomes in cervical and lumbar fusion. The 3DPT cage has advantage in fusion quality, subsidence severity, and bone\u2010cage interface contact than PEEK cage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13896","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:03:53Z","timestamp":1695963833000},"page":"2889-2900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Comparison between <scp>Three\u2010Dimensional<\/scp> Printed Titanium and <scp>PEEK<\/scp> Cages for Cervical and Lumbar Interbody Fusion: A Prospective Controlled Trial"],"prefix":"10.1111","volume":"15","author":[{"given":"Zhipeng","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Orthopedics The First People's Hospital of Shuangliu District  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-8657","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-0740","authenticated-orcid":false,"given":"Yueming","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-3323","authenticated-orcid":false,"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 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