{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:19:15Z","timestamp":1783703955913,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072386"],"award-info":[{"award-number":["82072386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102521"],"award-info":[{"award-number":["82102521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYGD21001"],"award-info":[{"award-number":["ZYGD21001"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recently, the MRI\u2010based vertebral bone quality (VBQ) score has been shown to correlate with Hounsfeld units (HU) value, dual\u2010energy X\u2010ray absorptiometry (DEXA) T\u2010score and predict osteoporotic fractures. Preoperative cervical HU value is an independent correlative factor for early titanium mesh cage (TMC) subsidence after anterior cervical corpectomy and fusion (ACCF). However, to date the direct association between cervical VBQ score and TMC subsidence has not been studied. This study aims to investigate the predictive effect of cervical VBQ score derived from sagittal non\u2010contrast\u2010enhanced T1\u2010weighted MRI on the early TMC subsidence after ACCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent one\u2010level ACCF from January 2016 to January 2020 were included. We retrospectively collected baseline data on age, sex, body mass index (BMI), disease type, level of surgery and radiology parameters. The cervical VBQ score was measured using preoperative non\u2010contrast\u2010enhanced T1\u2010weighted MRI. Univariate and multivariate logistic regression analysis were performed to screen the independent risk factors of TMC subsidence. The receiver operating characteristic (ROC) curve and area under curve (AUC) were performed to assess the predictive ability of TMC subsidence based on the cervical VBQ score. Spearman correlation analysis was used to determine the correlations between the cervical VBQ score and TMC subsidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 134 patients who underwent one\u2010level ACCF were included in this study, and 46 (34.33%) patients had TMC subsidence. Univariable analyses demonstrated that the age, TMC placement depth and VBQ score were associated with subsidence. The cervical VBQ score in the subsidence group was significantly higher than that in the no subsidence group (3.75\u2009\u00b1\u20090.45 <jats:italic>vs<\/jats:italic>. 3.20\u2009\u00b1\u20090.42, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The multivariate logistic regression analysis proved that the higher VBQ score (odds ratio[OR]\u2009=\u200913.563, 95% confidence interval [CI] 4.968\u2009\u2010\u200937.031, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was the only variable that significantly predicted subsidence. Using a VBQ score cutoff value of 3.445, the cervical VBQ score yielded a sensitivity of 69.6% and a specificity of 85.2% with an AUC of 0.810 to differentiate patients with subsidence and with no subsidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative higher cervical VBQ score is an independent risk factor for TMC subsidence after ACCF. The cervical VBQ score may be a valuable tool for assisting in distinguishing the presence of TMC subsidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13931","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:47:55Z","timestamp":1700214475000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Association between High Preoperative <scp>MRI<\/scp>\u2010based Vertebral Bone Quality (<scp>VBQ<\/scp>) Score and Titanium Mesh Cage Subsidence after Anterior Cervical Corpectomy and Fusion"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3331-3674","authenticated-orcid":false,"given":"Qiujiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Xia","sequence":"additional","affiliation":[{"name":"Operating Room of Anesthesia Surgery Center, West China Hospital, Sichuan University\/West China School of Nursing Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-0740","authenticated-orcid":false,"given":"Yueming","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute, West China Hospital, Sichuan University  Chengdu 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