{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:45:43Z","timestamp":1793825143123,"version":"4.6.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022\u2010YF05\u201001836\u2010SN"],"award-info":[{"award-number":["2022\u2010YF05\u201001836\u2010SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The ability of D\u2010dimer to diagnose periprosthetic joint infection (PJI) before revision hip or knee arthroplasty is still controversial, and the differences in diagnostic ability between serum\u2010 or plasma\u2010based assays of D\u2010dimer and fibrin (fibrinogen) degradation product (FDP) are uncertain. The prospective parallel study was performed to determine the ability of D\u2010dimer to diagnose PJI before revision hip or knee arthroplasty, and the differences in diagnostic ability between serum\u2010 or plasma\u2010based assays of D\u2010dimer and FDP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing knee or hip arthroplasty at our institution were prospectively enrolled into the following groups: those without inflammatory diseases who were undergoing primary arthroplasty (\u201cPrim\u201d group), those with inflammatory arthritis who were undergoing primary arthroplasty (\u201cPrim\/Inflam\u201d), those undergoing revision arthroplasty because of aseptic failure (\u201cRev\/Asept\u201d), or those undergoing revision arthroplasty because of PJI (\u201cRev\/PJI\u201d). The ability of preoperative levels of D\u2010dimer or FDP in serum or plasma to diagnose PJI in each group was assessed using areas under receiver operating characteristic curves (AUCs) and other diagnostic performance indicators. The diagnostic performance of these assays was compared with that of C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the final analysis, Prim included 42 patients; Prim\/Inflam, 40; Rev.\/Asept, 62; and Rev.\/PJI, 47. D\u2010dimer assays led to AUCs of 0.635 in serum and 0.573 in plasma, compared to 0.593 and 0.607 for FDP. Even in combination with CRP or ESR, these assays failed to perform as well as the combination of CRP and ESR for diagnosing PJI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Levels of D\u2010dimer or FDP in serum or plasma, whether used alone or together with CRP or ESR, are unreliable for diagnosing PJI before revision arthroplasty.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13935","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:13:55Z","timestamp":1700212435000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unreliability of Serum\u2010 or Plasma\u2010based Assays of D\u2010dimer or Fibrin (Fibrinogen) Degradation Product for Diagnosing Periprosthetic Joint Infection: A Prospective Parallel Study"],"prefix":"10.1111","volume":"16","author":[{"given":"Hong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopedic surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-8379","authenticated-orcid":false,"given":"Zeyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 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