{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:53:31Z","timestamp":1786679611836,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104882"],"award-info":[{"award-number":["82104882"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Medial opening\u2010wedge high tibial osteotomy (MOWHTO) is considered to be an effective treatment for symptomatic knee osteoarthritis (KOA) of isolated the medial compartment with varus alignment of the lower extremity. However, the choice of material to fill the void remains controversial. This study aims to evaluate the bone union of the osteotomy gap using a novel wedge\u2010shaped cancellous allograft after MOWHTO and its effect on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who underwent MOWHTO using a novel wedge\u2010shaped cancellous allograft combined with TomoFix locking compression plate (LCP) fixation between January 2016 and July 2020 were enrolled. The radiographic parameters including hip\u2010knee\u2010ankle angle (HKAA), medial proximal tibial angle (MPTA), femorotibial angle (FTA) and posterior tibial slope angle (PTSA) were measured between pre\u2010operative and post\u2010operative radiographs. Knee Society score (KSS) and range of motion (ROM) were assessed preoperatively and at last follow\u2010up. Patients included in this study were divided into two groups according to the correction angle: small correction group (&lt;\u200910\u00b0; SC group) and large correction group (\u2265\u200910\u00b0; LC group). The modified Radiographic Union score for tibial fractures (mRUST) was used to assess the difference in bone healing between the two groups at 1, 3, 6, and 12\u2009months postoperatively and at the final follow\u2010up. A paired student's <jats:italic>t<\/jats:italic> test was conducted for comparison of differences of the relevant data pre\u2010operatively and post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 82 patients (88 knees) were included in this study. The HKAA, MPTA, FTA and PTSA increased from \u22126.4\u00b0\u2009\u00b1\u20093.0\u00b0, 85.1\u00b0\u2009\u00b1\u20092.6\u00b0, 180.1\u00b0\u2009\u00b1\u20093.2\u00b0 and 7.7\u00b0\u2009\u00b1\u20094.4\u00b0 preoperatively to 1.2\u00b0\u2009\u00b1\u20094.3\u00b0 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 94.4\u00b0\u2009\u00b1\u20093.3\u00b0 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 171.0\u00b0\u2009\u00b1\u20092.8\u00b0 and 11.8\u00b0\u2009\u00b1\u20095.8\u00b0 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) immediately postoperatively, respectively. However, no significant statistic difference was found in above\u2010mentioned parameters at last follow\u2010up compared to immediate postoperative data (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). All patients in this study achieved good bone healing at the final follow\u2010up and no significant differences in mRUST scores were seen between the SC group and LC group. The KSS\u2010Knee score and KSS\u2010Function score improved significantly from 55.4\u2009\u00b1\u20093.7 and 63.3\u2009\u00b1\u20094.6 preoperatively to 86.4\u2009\u00b1\u20092.8 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 89.6\u2009\u00b1\u20092.9 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) at last follow\u2010up, respectively. Nevertheless, there was no significant difference in ROM between pre\u2010operation and last follow\u2010up (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For MOWHTO, the wedge\u2010shaped cancellous allograft was a reliable choice for providing good bone healing and clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13939","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T08:55:03Z","timestamp":1701161703000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone Healing and Clinical Outcome Following Medial Opening\u2010wedge High Tibial Osteotomy Using Wedge\u2010Shaped Cancellous Allograft"],"prefix":"10.1111","volume":"16","author":[{"given":"Jinlun","family":"Chen","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Orthopaedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Panyu Hospital of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-6483","authenticated-orcid":false,"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-1233","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of 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