{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:45:04Z","timestamp":1792622704982,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2503104"],"award-info":[{"award-number":["2022YFC2503104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20280"],"award-info":[{"award-number":["U22A20280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite the established success of total knee arthroplasty (TKA) with end\u2010stage osteoarthritis, there is a notable scarcity of research on its long\u2010term outcomes in individuals suffering from end\u2010stage Kashin\u2013Beck disease (KBD). This retrospective study aimed to assess the long\u2010term outcomes and effectiveness of clinical function, quality of life, and complications of TKA and end\u2010stage KBD patients in Tibetan highland areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective cohort included 43 KBD patients, comprising a total of 59 knees, who had undergone TKA at West China Hospital, Sichuan University between 2008 and 2021. Patients were subsequently followed up for a minimum of 3\u2009years, and received rigorous radiological and clinical assessments at 3, 6, and 12\u2009months post surgery, followed by annual examinations thereafter. The evaluation included various efficacy indices, including visual analogue scale (VAS) scores, hospital for special surgery (HSS) scores, functional score for adult Tibetans with Kashin\u2013Beck disease (FSAT\u2010KBD), and radiographic findings. Comparison of indicators within the same group was conducted using one\u2010way repeated\u2010measures analysis of variance or paired sample <jats:italic>t<\/jats:italic>\u2010tests, whereas between\u2010group differences were compared using an independent <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Throughout the average follow\u2010up duration of 10.8\u2009years, patients experienced a substantial reduction in knee pain and noteworthy functional improvement. The VAS scores decreased significantly from 77.47\u2009\u00b1\u20094.12\u2009mm before surgery to 10.91\u2009\u00b1\u20091.97\u2009mm after surgery, indicating considerable alleviation of knee pain. The HSS scores improved markedly, increasing from 44.26\u2009\u00b1\u20094.95 preoperatively to 91.26\u2009\u00b1\u20094.37, indicating enhanced joint function. Similarly, the FSAT\u2010KBD exhibited positive progression, increasing from 25.90\u2009\u00b1\u20093.12 to 36.95\u2009\u00b1\u20093.54. Importantly, at the last follow\u2010up, none of the patients presented with periprosthetic infection, prosthesis loosening, or periprosthetic fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At long\u2010term follow\u2010up, compared with patients in the preoperative period, patients in Tibetan highland areas with KBD of the knee who underwent TKA benefited from a significant reduction in pain, improvement in joint function, and satisfactory improvement in quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.14068","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T03:15:50Z","timestamp":1713755750000},"page":"1300-1307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Long\u2010term Efficacy of Total Knee Arthroplasty on End\u2010stage <scp>Kashin\u2013Beck<\/scp> Disease of the Knee in Highland Tibetan Areas Patients: A Retrospective Study with 10\u2010Year Follow\u2010up"],"prefix":"10.1111","volume":"16","author":[{"given":"Haocheng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongrui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-4756","authenticated-orcid":false,"given":"Zongke","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,21]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"343","article-title":"The history of Kashin\u2010Beck disease","volume":"89","author":"Sokoloff L","year":"1989","journal-title":"N Y State J 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