{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:14:10Z","timestamp":1773029650083,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Total hip arthroplasty (THA) effectively treats end\u2010stage hemophilic hip arthropathy. Given hemophilia's unique characteristics, perioperative bleeding remains a significant risk for patients undergoing THA. Tranexamic acid (TXA), an efficient antifibrinolytic agent, may benefit the outcomes of THA for patients with hemophilia (PWH). This study aims to explore the clinical efficacy of intra\u2010articular injection of TXA in treating perioperative bleeding in PWH and assess its additional clinical benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective study comprised data of PWH who received THA from January 2015 to December 2021 in the research center. A total of 59 individuals were included in the study, divided into a TXA group (<jats:italic>n<\/jats:italic>\u2009=\u200931) and a non\u2010TXA group (<jats:italic>n<\/jats:italic>\u2009=\u200928). We compared various parameters, including total blood loss (TBL), visible blood loss (VBL), occult blood loss (OBL), intraoperative coagulation factor VIII (FVIII) consumption, perioperative total FVIII consumption, hemoglobin (HB), erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP), length of hospital stay, hospitalization costs, length of surgery, total protein, activated partial thromboplastin time (APTT), D\u2010dimer, rate of joint swelling, hip joint range of motion (ROM), visual analogue scale (VAS), and Harris hip joint function scale (HHS) between the two groups. Follow\u2010up assessments were conducted for up to 24\u2009months. A Student's <jats:italic>t<\/jats:italic> test was utilized for the statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study demonstrated that intra\u2010articular TXA effectively reduced TBL (1248.19\u2009\u00b1\u2009439.88\u2009mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), VBL (490.32\u2009\u00b1\u2009344.34\u2009mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and OBL (757.87\u2009\u00b1\u2009381.48\u2009mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) in PWH who underwent THA. TXA demonstrated effectiveness in reducing VAS scores on POD1, POD7, and POD14 and joint swelling rates on POD1, POD7, POD14, and at discharge (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, the TXA group achieved higher HHS ratings at all follow\u2010up time points (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), showing superior hip joint mobility, lower postoperative inflammation levels, reduced factor VIII consumption during surgery, and less postoperative nutritional loss. No statistically significant differences were observed between the two groups in terms of hospital stay, hospitalization costs, surgery duration, and coagulation indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intra\u2010articular injection of TXA reduces perioperative bleeding in PWH undergoing THA while also improving joint mobility, post\u2010operative rehabilitation, and quality of life. This may provide value for the future application of TXA in PWH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.14126","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T10:35:15Z","timestamp":1717410915000},"page":"1673-1683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Efficacy of Intra\u2010articular Tranexamic Acid Injection in the Management of Hemophilia with Total Hip Arthroplasty: A 24\u2010month Retrospective Cohort Study"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0719-4683","authenticated-orcid":false,"given":"Hai","family":"Su","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou 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