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The Zoned Trabecular Bone Cementless Knee is a novel implant designed for cementless TKA which aims to achieve excellent initial fixation, promoting effective osseointegration. The aim of this research was to compare the early clinical and radiographic results of this cementless TKA with cemented TKA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between September 2021 and April 2022, 64 patients (64 knees) were recruited in this prospective randomized controlled trial to receive either cementless 3D\u2010printed trabecular metal TKA or a cemented posterior stabilized TKA. Preoperative and postoperative clinical evaluations, including the range of motion (ROM), Knee Society Score (KSS), and the Reduced Western Ontario and MacMaster Universities Score (WOMAC), were conducted and analyzed for comparison. Radiographs and computed tomography scans were utilized to assess the initial fixation. The complications between the two groups were also recorded and compared. Continuous data were analyzed for significance using independent\u2010samples t\u2010test or the Mann\u2013Whitney U test and categorical data were analyzed using chi\u2010squared or Fisher's exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups demonstrated significant enhancement at 12\u2009months follow\u2010up in the ROM compared with baseline (ROM: 94.7\u2009\u00b1\u200923.4 vs. 113.1\u2009\u00b1\u200912.3 in cementless group and 96.5\u2009\u00b1\u200914.7 vs. 111.0\u2009\u00b1\u200912.8 in cemented group, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, no statistical differences were observed between the two groups in postoperative ROM, KSS, or WOMAC score. The radiographs and computed tomography scans showed similar results, including radiolucent lines and osteolysis in either femoral or tibial. Additionally, there was no statistical difference in the overall complication rate between the two groups. Notably, one patient in the cementless TKA group required revision for periprosthetic infection as the end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel 3D\u2010printed trabecular metal cementless TKA achieved comparable clinical outcomes and initial fixation to cemented TKA in early stage. Longer\u2010term examination is necessary to validate these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.14178","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T17:48:31Z","timestamp":1724348911000},"page":"2671-2679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Randomized Controlled Trial of a Novel Cementless <scp>vs.<\/scp> Cemented Total Knee Arthroplasty: Early Clinical and Radiographic Outcomes"],"prefix":"10.1111","volume":"16","author":[{"given":"Enze","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery West China Hospital, West China Medical School, Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"West China School of Nursing, Sichuan University\/Department of Orthopedics West China Hospital, Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery West China Hospital, West China Medical School, Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery West China Hospital, West China Medical School, Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery West China Hospital, West China Medical School, Sichuan University  Chengdu People's Republic of 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