{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:16:54Z","timestamp":1780697814062,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172065"],"award-info":[{"award-number":["82172065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z181100001718195"],"award-info":[{"award-number":["Z181100001718195"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The clinical management of partial bone defects in lower limbs, particularly those resulting from osteomyelitis, remains a significant challenge. This study aimed to systematically evaluate the effectiveness of 3D\u2010printed porous Ti6Al4V prostheses in addressing osteomyelitis\u2010induced partial bone defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We established a comprehensive protocol for utilizing 3D\u2010printed prostheses for bone defect repair, encompassing 3D simulation of prosthesis implantation and internal fixation, finite element analysis (FEA), and clinical implementation. Mimics software facilitated simulation of fixation patterns and screw lengths. FEA modeled bone defects in the distal metaphyseal femur and distal diaphyseal tibia to assess changes in stress conduction pre\u2010 and post\u2010prosthesis implantation. The clinical study involved eight patients (average age: 56.3\u2009years) with an average defect length of 14.9\u2009cm. Postoperative outcomes were evaluated using X\u2010rays and the Lower Extremity Functional Scale (LEFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FEA demonstrated that the implanted prostheses effectively shared stress and reduced the load on residual bone in both models, thus lowering the risk of fractures under external forces. The average follow\u2010up period was 24.5\u2009months, with patients initiating weight\u2010bearing activities on average 7.8\u2009days post\u2010surgery. Serial postoperative X\u2010rays demonstrated long\u2010term stability of the prostheses, with progressive bone regeneration around and integration with the prostheses. While two patients experienced infection recurrence requiring prosthesis removal and debridement, the remaining six showed significant improvement in LEFS scores, increasing from 31.5 preoperatively to 61.0 at the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>3D\u2010printed porous Ti6Al4V prostheses effectively restore anatomical integrity and optimize stress conduction in lower limbs, resulting in substantial functional recovery. This innovative approach shows promise for wider clinical adoption and warrants further investigation in medical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.14268","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T08:40:43Z","timestamp":1729500043000},"page":"115-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Applying <scp>3D<\/scp>\u2010Printed Porous <scp>Ti6Al4V<\/scp> Prostheses to Repair Osteomyelitis\u2010Induced Partial Bone Defects of Lower Limbs: Finite Element Analysis and Clinical Outcomes"],"prefix":"10.1111","volume":"17","author":[{"given":"Bingchuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Peking University Third Hospital  Beijing China"},{"name":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Peking University Third Hospital  Beijing China"},{"name":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Peking University Third Hospital  Beijing China"},{"name":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Peking University Third Hospital  Beijing China"},{"name":"Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caimei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing AKEC Medical Co., Ltd.  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