{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:19:28Z","timestamp":1784351968525,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Rotator cuff retear after arthroscopy repair is a difficult complication that is often due to poor tendon\u2013bone healing. Decellularized amniotic membrane (DAM) has a variety of bioactive substances which have great potential to enhance tendon\u2013bone healing. However, DAM has three layers, of which the middle basement layer is dense and thick. Whether DAM will hinder tendon\u2013bone healing of rotator cuff after surgical repair is unclear. Our study aims to investigate the effect of DAM on tendon\u2013bone healing of the rotator cuff after surgical repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three Sprague\u2013Dawley (SD) rats were selected to establish unilateral supraspinatus (ST) tear models and were randomly treated with only suturing repair (OSR group, <jats:italic>n<\/jats:italic>\u2009=\u200911), and suturing repair with DAM placed between the ST and bone (DAM group, <jats:italic>n<\/jats:italic>\u2009=\u200911). In the normal control group (NCT group, <jats:italic>n<\/jats:italic>\u2009=\u200911), the supraspinatus was only exposed but not detached or repaired. After 4\u2009weeks the rats were sacrificed. The assessment of specimens was conducted by micro\u2010CT analysis, histopathological evaluation, and biomechanical testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DAM group had a significantly higher ultimate load to failure, new bone volume, and histological evaluation at 4\u2009weeks after surgery than the OSR group. When comparing the DAM group to the NCT group, the DAM group performed slightly worse in biomechanical testing, micro\u2010CT analysis, and histological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When placed between tendon and bone at the rotator cuff footprint, DAM, despite its dense and thick basement layer, does not impede tendon\u2013bone healing after surgical repair for rotator cuff injury, but rather promotes increased healing quality and biomechanical properties. However, the healing quality and biomechanical properties are still lower than that of the normal rotator cuff, and further improvement should be made to the application strategy of a DAM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.14316","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T09:44:16Z","timestamp":1733910256000},"page":"575-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Decellularized Amniotic Membrane on the Tendon\u2013Bone Integration in Rotator Cuff Repair: A Comparative Rat Model Study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-2959","authenticated-orcid":false,"given":"Jiangtao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Fourth Medical Center of Chinese PLA General Hospital  Beijing China"},{"name":"Chinese PLA Medical School  Beijing China"},{"name":"Department of Orthopedics The 980th Hospital of PLA Joint Logistics Support Forces  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Fourth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiating","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Third Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"An","sequence":"additional","affiliation":[{"name":"Chinese PLA Medical School  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese PLA Medical School  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Foot &amp; Ankle Section University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5295-6632","authenticated-orcid":false,"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Fourth Medical Center of Chinese PLA General Hospital  Beijing China"},{"name":"Department of Orthopedics Hainan Hospital of Chinese PLA General Hospital  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0000000000000207"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520904022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119889049"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00039"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-020-09660-w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2017.10.030"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.657584"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2019.11.028"},{"key":"e_1_2_12_10_1","article-title":"Use of a Novel, Reinforced, Low Immunogenic, Porcine Small Intestine Submucosa Patch to Repair a Supraspinatus Tendon Defect in a Rabbit Model","volume":"12","author":"Zhang X. 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