{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:15:08Z","timestamp":1784632508539,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH273"],"award-info":[{"award-number":["ZR2022MH273"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023LZY012"],"award-info":[{"award-number":["ZR2023LZY012"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In patients with lumbar spinal stenosis (LSS), prolonged compression of the epidural venous plexus heightens the risk of bleeding and hematoma during minimally invasive surgery. While absorbable fluid gelatin, an animal protein\u2013based hemostatic agent, is available, its effectiveness in lumbar endoscopic unilateral laminotomy with bilateral decompression (LE\u2010ULBD) remains debated. Our research aims to conduct a prospective randomized controlled trial to investigate the effectiveness and safety of this hemostatic material in patients undergoing LE\u2010ULBD for LSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2023 to July 2024, a total of 90 patients with LSS who underwent LE\u2010ULBD were enrolled in this study. The 90 patients were randomly divided into two groups: fluid gelatin group (45 cases, using fluid gelatin) and null\u2010fluid gelatin group (45 cases, not using fluid gelatin). Primary outcomes included the success rate of achieving hemostasis within 3\u2009min and symptomatic postoperative epidural hematoma (SPEH). Secondary outcomes encompassed surgical time, intraoperative blood loss, perioperative blood loss, length of stay, and complications. Independent sample t tests were used to compare continuous data. Chi\u2010squared tests and Fisher's exact probability tests were used to analyze the categorical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The success rate of achieving hemostasis within 3\u2009min (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) was significantly higher in fluid gelatin group compared to that in the null\u2010fluid gelatin group, and perioperative blood loss (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and surgical time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) were notably lower in the fluid gelatin group. However, there were no statistically significant differences between the two groups regarding intraoperative blood loss, length of stay, and complications, such as SPEH, allergy, and thrombus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with LSS undergoing LE\u2010ULBD surgery, using fluid gelatin can achieve rapid intraoperative hemostasis, shorten surgical time, and reduce perioperative blood loss without causing complications. Therefore, the conventional use of fluid gelatin in LE\u2010ULBD surgery is an effective and safe strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.14373","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:02:34Z","timestamp":1741708954000},"page":"1162-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Fluid Gelatin for Lumbar Spinal Stenosis Undergoing Lumbar Endoscopic Bilateral Decompression: A Prospective, Randomized Controlled Trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Hao","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzhan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5039-7861","authenticated-orcid":false,"given":"Weiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Weifang People's Hospital Shandong Second Medical University  Weifang China"},{"name":"Digital Spine and Minimally Invasive Research Institute Shandong Second Medical University  Weifang China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation Weifang People's Hospital  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Li\u2010Ling","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics, West China Second University Hospital Sichuan University  Chengdu 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