{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:22:51Z","timestamp":1790115771587,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023LZY012"],"award-info":[{"award-number":["ZR2023LZY012"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In patients with lumbar spinal stenosis (LSS) undergoing unilateral biportal endoscopic unilateral laminotomy for bilateral decompression (UBE\u2010ULBD), damage to the epidural venous plexus often leads to bleeding, increasing the risk of surgical complications. Surgiflo Hemostatic Matrix (SHM) is a gelatin extracted from porcine skin, used for intraoperative hemostasis. This study aims to evaluate the effectiveness and safety of using SHM during UBE\u2010ULBD surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2023 to July 2024, a total of 96 patients with LSS underwent UBE\u2010ULBD surgery. These 96 patients were randomly divided into two groups: the SHM group (48 patients, using flowable gelatin) and the non\u2010SHM group (48 patients, not using flowable gelatin). The primary outcomes included intraoperative blood loss, postoperative drainage volume, and the 3\u2010min hemostasis success rate. Secondary outcomes included symptomatic postoperative epidural hematoma (SPEH), surgical time, postoperative hospital stay, hospitalization costs, and complications. We used independent sample <jats:italic>t<\/jats:italic>\u2010tests to compare continuous data, and chi\u2010square tests or Fisher's exact tests to analyze categorical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intraoperative blood loss and postoperative drainage volume in the SHM group were significantly less than those in the non\u2010SHM group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and the 3\u2010min hemostasis success rate in the SHM group was significantly higher than that in the non\u2010SHM group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There were no statistically significant differences between the two groups regarding SPEH, postoperative hospital stay, hospitalization costs, and complications such as thrombosis formation and allergic reactions. However, the surgical time in the SHM group was significantly shorter than that in the non\u2010SHM group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When patients with LSS undergo UBE\u2010ULBD, the use of fluid gelatin can effectively reduce intraoperative and postoperative bleeding without introducing additional complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.70009","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T10:04:53Z","timestamp":1740564293000},"page":"1340-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Hao","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"},{"name":"Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University  Weifang Shandong China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation, Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"},{"name":"Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University  Weifang Shandong China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation, Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"},{"name":"Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University  Weifang Shandong China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation, Weifang People's Hospital  Weifang Shandong 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Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation, Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzhan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"},{"name":"Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University  Weifang Shandong China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation, Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5039-7861","authenticated-orcid":false,"given":"Weiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Weifang People's Hospital, Shandong Second Medical University  Weifang Shandong China"},{"name":"Digital Spine and Minimally Invasive Research Institute, Shandong Second Medical University  Weifang Shandong China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Orthopedic Rare Diseases Prevention and Digital Technique Medicine\u2010Engineering Transformation, Weifang People's Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Li\u2010Ling","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics, West China Second University Hospital, Sichuan University  Chengdu Sichuan 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