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Understanding changes in calf muscle and Achilles tendon (AT) stiffness after LAS may shed light on mechanisms underlying impaired function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of acute LAS on the mechanical properties of the calf muscles and the Achilles tendon, ankle function, pain, edema, and strength.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This controlled observational study was conducted from August 2023 to January 2025. Fourteen participants with acute LAS and 14 healthy controls were evaluated twice, 6\u2009weeks apart. Shear wave elastography (SWE) assessed the stiffness of the triceps surae and AT. Ankle function, pain, and edema were evaluated using the Foot and Ankle Outcome Score, Visual Analog Scale, and figure\u2010of\u2010eight method. Plantar flexion strength was measured via isometric dynamometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in stiffness were found between or within groups (soleus: <jats:italic>p<\/jats:italic>\u2009=\u20090.932; MG: <jats:italic>p<\/jats:italic>\u2009=\u20090.760; LG: <jats:italic>p<\/jats:italic>\u2009=\u20090.800; AT: <jats:italic>p<\/jats:italic>\u2009=\u20090.070), although a time effect (<jats:italic>p<\/jats:italic>\u2009=\u20090.005, \u03b7<jats:sup>2<\/jats:sup>\u2009=\u20090.269) indicated a general increase in AT stiffness over time (MD\u2009=\u2009\u22120.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.05, d\u2009=\u20092.86). At baseline, the LAS group exhibited reduced ankle function (MD\u2009=\u20093.43, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u20092.20), increased pain (MD\u2009=\u20091.88, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u20091.86), and greater edema (MD\u2009=\u2009\u221251.27, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u2009\u22123.58). Over time, improvements were noted in function (MD\u2009=\u2009\u221237.04, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u20092.27), pain (MD\u2009=\u20092.66, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u2009\u22121.31), and edema (MD\u2009=\u20091.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.014, d\u2009=\u2009\u22120.95), but ankle function remained lower in the LAS group at follow\u2010up (MD\u2009=\u2009\u221214.17, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u2009\u22121.79). For plantar flexion strength, no group \u00d7 time interaction was found (<jats:italic>p<\/jats:italic>\u2009=\u20090.745), but a group effect indicated lower peak torque in the LAS group (MD\u2009=\u2009\u221232.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.012, d\u2009=\u2009\u22123.82). A time effect (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, \u03b7<jats:sup>2<\/jats:sup>\u2009=\u20090.622) showed increased torque across both groups (MD\u2009=\u2009\u221218.74, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, d\u2009=\u20093.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LAS reduces ankle function and leads to pain and edema but does not induce notable changes in calf muscle or AT stiffness within 6\u2009weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.70082","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T03:33:47Z","timestamp":1748576027000},"page":"2082-2092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Lateral Ankle Sprain Impairs Function and Strength Without Altering Muscle or Tendon Stiffness: A Controlled Observational Study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8286-4032","authenticated-orcid":false,"given":"Pedro Bainy","family":"Franz","sequence":"first","affiliation":[{"name":"Laboratory of Muscle and Tendon Plasticity Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto","family":"de Souza J\u00fanior","sequence":"additional","affiliation":[{"name":"University Center of the Federal District \u2013 UDF  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hort\u00eancia Cordeiro","family":"de Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle and Tendon Plasticity Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estev\u00e3o","family":"de Souza Diniz","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle and Tendon Plasticity Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"de Brito Aguiar","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle and Tendon Plasticity Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeam Marcel","family":"Geremia","sequence":"additional","affiliation":[{"name":"Exercise Research Laboratory Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Mansur","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle and Tendon Plasticity Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"de C\u00e1ssia Marqueti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Analysis Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Luiz Quagliotti","family":"Durigan","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle and Tendon Plasticity Graduate Program in Rehabilitation Science, Faculty of Health Sciences and Technologies, University of Bras\u00edlia  Brasilia Brazil"},{"name":"Rehabilitation Sciences Program University of Brasilia  Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"issue":"10","key":"e_1_2_10_2_1","first-page":"1714","article-title":"Acute Ankle Sprain: An Update","volume":"74","author":"Ivins D.","year":"2006","journal-title":"American Family Physician"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062\u20106050\u2010447\u201017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-013-0102-5"},{"issue":"6","key":"e_1_2_10_5_1","first-page":"426","article-title":"Epidemiology of Joint Dislocations and Ligamentous\/Tendinous Injuries Among 2,700 Patients: Five\u2010Year Trend of a Tertiary Center in Iran","volume":"5","author":"Nabian M. 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