{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:04:00Z","timestamp":1791065040488,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Amputation has a profound impact on an individual's quality of life (QoL) and functional ability. While socket prostheses are the current first\u2010line treatment, they often cause socket\u2010related issues. Bone\u2010anchored prostheses (BAP) have been introduced to address these problems and improve the amputee experience. This systematic review and meta\u2010analysis aim to compare the QoL between bone\u2010anchored and socket prostheses in transfemoral amputees. A systematic review and meta\u2010analysis were conducted from November 2023 to July 2024, following PRISMA guidelines. Databases including PUBMED, EMBASE, Scopus, Cochrane, and Web of Science were searched. Studies of single\u2010arm trial design comparing pre\u2010 and post\u2010operative outcomes were selected based on specific inclusion and exclusion criteria. Statistical analysis was performed using inverse variance with a random effect model. The primary outcome was QoL, measured using the Questionnaire for Persons with a Transfemoral Amputation (Q\u2010TFA) and 36\u2010Item Short Form Survey (SF\u201036), and the secondary outcome was mobility, assessed by the 6\u2010Minute Walk Test (6MWT). Subgroup analyses compared different types of BAP (Press\u2010fit vs. Screw\u2010type) on QoL. Thirteen NRCTs with 398 participants were included. Significant improvements in QoL were observed in all Q\u2010TFA domains and the SF\u201036 Physical Component Score (PCS), but not in the SF\u201036 Mental Component Score (MCS). Mobility improved significantly as measured by the six\u2010minute walk test (6MWT). No significant differences in QoL were found between Press\u2010fit and Screw\u2010type BAP implants. Overall, BAP significantly improve both QoL and mobility, but study limitations currently restrict their use to individuals with socket\u2010related complications. As such, it cannot yet be universally recommended as a first\u2010line intervention.<\/jats:p>","DOI":"10.1111\/os.70086","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T08:40:31Z","timestamp":1752828031000},"page":"2234-2254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Quality of Life in Transfemoral Amputee Using Bone\u2010Anchored Prostheses vs. Socket Prostheses: A Systemic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-7239","authenticated-orcid":false,"given":"Janice","family":"Tan","sequence":"first","affiliation":[{"name":"Barts Cancer Institute Queen Mary University of London  London UK"},{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafisa","family":"Zilani","sequence":"additional","affiliation":[{"name":"Barts Cancer Institute Queen Mary University of London  London UK"},{"name":"GKT School of Medical Education King's College University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezaul","family":"Karim","sequence":"additional","affiliation":[{"name":"Barts Cancer Institute Queen Mary University of London  London UK"},{"name":"Department of Laparoscopic Surgery and Surgical Skills, Barts Cancer Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijendra","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Laparoscopic Surgery and Surgical Skills, Barts Cancer Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0309364620948649"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2017.2775100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-021-00944-x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24445"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2023.105954"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fresc.2024.1336042"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00043"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120836"},{"issue":"11","key":"e_1_2_13_10_1","first-page":"900","article-title":"Safety of Osseointegrated Implants for Transfemoral Amputees: A Two\u2010Center Prospective Cohort Study","volume":"98","author":"Al Muderis M.","year":"2016","journal-title":"Journal of Bone and Joint Surgery. 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