{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:40:35Z","timestamp":1793029235492,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC0568"],"award-info":[{"award-number":["2024NSFSC0568"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0126900"],"award-info":[{"award-number":["2023YFE0126900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pelvic reconstruction with conventional 3D\u2010printed prostheses faces a critical trade\u2010off, where achieving sufficient porosity for optimal bone ingrowth often compromises essential mechanical stability. To address this challenge, this study evaluates the clinical outcomes of 3D\u2010printed hemipelvic prostheses incorporating re\u2010entrant chiral structure (RCS), a novel negative Poisson's ratio design, in patients undergoing pelvic reconstruction following tumor resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on 15 patients (eight females and seven males; mean age: 39.3\u2009\u00b1\u200911.7\u2009years) with pelvic malignancies who underwent reconstruction using 3D\u2010printed hemipelvic prostheses incorporating RCS between March 2018 and June 2023. The diagnoses included osteosarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), Ewing's sarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), chondrosarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), and high\u2010grade soft tissue sarcoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092). All patients were staged as IIB according to the Enneking system, except for one case of Ewing's sarcoma (stage III). Neoadjuvant chemotherapy (four cycles) was administered to six osteosarcoma patients, and one Ewing's sarcoma patient received six cycles, while other patients proceeded directly to surgery. Patient outcomes were systematically evaluated through oncological status, functional performance (MSTS\u201093 score), pain assessment (VAS score), surgical parameters, complications, and radiographic analysis using Tomosynthesis Shimadzu Metal Artifact Reduction Technology (T\u2010SMART).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the latest follow\u2010up (44.5\u2009\u00b1\u20099.4\u2009months), 13 patients (86.7%) remained disease\u2010free; one patient (6.7%) experienced local recurrence requiring revision surgery, and one patient (6.7%) died of metastatic complications at 32\u2009months post\u2010surgery. Functional outcomes showed significant improvement, with mean MSTS\u201093 scores increasing from 14.5\u2009\u00b1\u20091.1 preoperatively to 25.8\u2009\u00b1\u20091.3 at final follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Pain control was satisfactory, with VAS scores decreasing from 5.5\u2009\u00b1\u20090.6 to 1.5\u2009\u00b1\u20090.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean surgical duration was 289.3\u2009\u00b1\u200930.4\u2009min, with an average intraoperative blood loss of 3540\u2009\u00b1\u2009621.5\u2009mL. Early complications included delayed wound healing in three cases (20%), successfully managed with wound care protocols and VAC therapy. One patient (6.7%) developed deep prosthetic infection at 14\u2009months post\u2010surgery, necessitating a two\u2010stage revision procedure. No mechanical failures, aseptic loosening, or prosthesis fractures were observed during the follow\u2010up period. Radiographic analysis demonstrated progressive bone ingrowth into the RCS porous regions in all cases, with no signs of osteolysis or implant migration in the remaining prostheses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>D\u2010printed custom hemipelvic prostheses with RCS offer an effective solution for pelvic reconstruction by achieving an optimal balance between mechanical stability and biological integration, leading to promising clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/os.70159","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T03:15:07Z","timestamp":1755832507000},"page":"3067-3077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Application of\n                    <scp>3D<\/scp>\n                    \u2010Printed Custom Hemipelvic Prostheses With Re\u2010Entrant Chiral Structure in Reconstruction After Pelvic Tumor Resection"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0021-6840","authenticated-orcid":false,"given":"Linyun","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Surgery West China Hospital, Sichuan University\/West China School of Nursing  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Surgery West China Hospital, Sichuan University\/West China School of Nursing  Chengdu Sichuan 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