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Spinal involvement, particularly the development of scoliosis, is one of the most serious clinical manifestations of OI, significantly impacting patients' quality of life. Scoliosis in OI is characterized by early onset and rapid progression, complicating its treatment and necessitating special attention. This review article consolidates the results of contemporary molecular\u2010genetic studies on spinal deformities in children with OI and examines the risk factors for their progression. It provides an overview of existing methods for treating scoliotic deformities in OI, including surgical and conservative approaches, and discusses prospects for the implementation of new therapeutic strategies. The aim of the review is to enhance the understanding of the pathogenesis of spinal deformities in OI and to contribute to the development of more effective methods for their diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/os.70170","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T07:26:47Z","timestamp":1758698807000},"page":"3036-3047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric Scoliosis in Osteogenesis Imperfecta: From Genetic Mechanisms to Therapeutic Strategies"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-7193","authenticated-orcid":false,"given":"Vladislav","family":"Muldiiarov","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Acute Care Surgery University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8461-1938","authenticated-orcid":false,"given":"Keely","family":"Buesing","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Acute Care Surgery University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-9412","authenticated-orcid":false,"given":"Maegen J.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.64B1.7068718"},{"issue":"7","key":"e_1_2_10_3_1","first-page":"925","article-title":"The Spine in Osteogenesis Imperfecta","volume":"60","author":"Benson D. 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