{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:39:47Z","timestamp":1775083187770,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H170002"],"award-info":[{"award-number":["LY20H170002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n Hyperuricemia, characterized by elevated serum uric acid levels without acute gout symptoms, may influence postoperative outcomes after total knee arthroplasty (\n TKA<\/jats:styled-content>\n ). This study aimed to evaluate the impact of hyperuricemia on postoperative inflammatory responses, complications, and mid\u2010term functional outcomes in patients undergoing primary\n TKA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a retrospective cohort study. We identified all patients who had undergone primary\n TKA<\/jats:styled-content>\n from April 1, 2015, to March 30, 2016. Patients were grouped by uric acid level. The knee society score (\n KSS<\/jats:styled-content>\n ) and hospital for special surgery knee score (\n HSS<\/jats:styled-content>\n ) before the surgery and 6\u2009years after the surgery were recorded. Statistical analyses included\n t<\/jats:italic>\n \u2010tests, chi\u2010square tests, and regression analyses to assess the influences of uric acid levels on C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ) levels, body temperature, functional scores, and local inflammatory response. The influence of the uric acid level on the local inflammatory response was also analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 614 patients, 140 had hyperuricemia, and 474 had normal uric acid levels. The hyperuricemia group had a higher unplanned readmission rate (11.4% vs. 5.7%,\n p<\/jats:italic>\n \u2009<\u20090.05) and longer hospital stay (10.75 vs. 9.54\u2009days,\n p<\/jats:italic>\n \u2009=\u20090.002).\n CRP<\/jats:styled-content>\n levels were significantly greater in the hyperuricemia group (\n OR<\/jats:styled-content>\n \u2009=\u200934.64, 95%\n CI<\/jats:styled-content>\n : 27.99\u201341.30,\n p<\/jats:italic>\n \u2009<\u20090.001), and the incidence of the local inflammatory response was greater (42.1% vs. 9.5%,\n p<\/jats:italic>\n \u2009<\u20090.01). The diagnostic accuracy for uric acid in the local inflammatory response was 0.742 (\n AUC<\/jats:styled-content>\n ). Improvements in the\n KSS<\/jats:styled-content>\n clinical score (\n p<\/jats:italic>\n \u2009<\u20090.01),\n KSS<\/jats:styled-content>\n functional score (\n p<\/jats:italic>\n \u2009<\u20090.01), and\n HSS<\/jats:styled-content>\n score (\n p<\/jats:italic>\n \u2009<\u20090.01) were lower in the hyperuricemia group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Hyperuricemia is associated with significantly elevated postoperative\n CRP<\/jats:styled-content>\n levels, a higher unplanned readmission rate, and substantially poorer mid\u2010term functional outcomes after\n TKA<\/jats:styled-content>\n . These patients also demonstrate increased inflammatory complications. These findings support preoperative uric acid screening to identify high\u2010risk patients for targeted management.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Relevance<\/jats:title>\n Level III.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n ClinicalTrials.gov identifier: NCT05476367.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/os.70197","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T02:53:32Z","timestamp":1762484012000},"page":"3477-3487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Outcomes of Patients With Hyperuricemia After Total Knee Arthroplasty: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"17","author":[{"given":"Jincong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Joint and Limb Surgery Yangming Hospital Affiliated to Ningbo University Yuyao Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Joint and Limb Surgery Yangming Hospital Affiliated to Ningbo University Yuyao Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheyuan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Joint and Limb Surgery Yangming Hospital Affiliated to Ningbo University Yuyao Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9200-8856","authenticated-orcid":false,"given":"Xuding","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Joint and Limb Surgery Yangming Hospital Affiliated to Ningbo University Yuyao Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000679"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40807"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2019.1660048"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081919"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41038"},{"issue":"2","key":"e_1_2_13_7_1","first-page":"66","article-title":"The Economic Value of Customized Versus Off\u2010The\u2010Shelf Knee Implants in Medicare Fee\u2010For\u2010Service Beneficiaries","volume":"12","author":"O'Connor M. 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