{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:59:40Z","timestamp":1781643580913,"version":"3.54.5"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Steroid\u2010induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses. The increasing clinical use of glucocorticoids has led to a rise in the incidence of steroid\u2010induced osteonecrosis of the femoral head, yet its precise molecular mechanisms remain incompletely understood, posing challenges for clinical management. This review proposes that the \u201cGC\u2010induced metabolic\u2010inflammatory\u2010oxidative stress vicious cycle\u201d serves as the core driver propelling the activation of the SONFH multi\u2010pathway PCD network. Centered on this thesis, the review systematically examines the synergistic and antagonistic interactions among PCD pathways\u2014including pyroptosis, autophagy, and ferroptosis\u2014in SONFH, emphasizing the pivotal role of mitochondrial dysfunction and ROS bursts. This framework not only integrates the independent functions of each PCD pathway but also reveals their interwoven molecular networks, offering novel perspectives for developing multi\u2010target synergistic therapeutic strategies.<\/jats:p>","DOI":"10.1111\/os.70229","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:04:43Z","timestamp":1765591483000},"page":"16-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Progress of Programmed Cell Death in Steroid\u2010Induced Osteonecrosis of the Femoral Head"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9776-984X","authenticated-orcid":false,"given":"Zhi","family":"Kong","sequence":"first","affiliation":[{"name":"Medical School of Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Tianjin University Tianjin Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"issue":"7","key":"e_1_2_21_2_1","first-page":"2710","article-title":"Correlation Between miR\u20101207\u20105p Expression With Steroid\u2010Induced Necrosis of Femoral Head and VEGF Expression","volume":"23","author":"Chao P. 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