{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:45Z","timestamp":1792678065918,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504300"],"award-info":[{"award-number":["2022YFC2504300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["82422045"],"award-info":[{"award-number":["82422045"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hip fracture causes significant morbidity and mortality, necessitating the identification of biomarkers for risk stratification. This study aimed to evaluate the association between N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) and incidence of postoperative complications and the 2\u2010year all\u2010cause mortality among hip fracture patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study involved 2595 patients aged from 45\u2009years who received surgery for hip fracture between 2000 and 2022. Preoperative NT\u2010proBNP levels were used to divide patients into three groups: low (&lt;\u2009123.27\u2009pg\/mL), moderate (123.27\u2013349.93\u2009pg\/mL), and high (&gt;\u2009349.93\u2009pg\/mL) NT\u2010proBNP group. Multivariate logistic regression and Cox proportional hazards models were used to evaluate the odds ratio (OR) for postoperative complications and the hazard ratio (HR) for mortality, after adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post\u2010operative complications were reported in 171 (6.59%) patients with mortality of 226 (8.71%) during the 2\u2010year follow\u2010up. Compared to patients with low NT\u2010proBNP group, the adjusted odds ratio for postoperative complications was 1.21 (95% CI 0.69\u20132.15) for those in the moderate NT\u2010proBNP group and 2.33 (95% CI 1.35\u20134.03) for those in the high NT\u2010proBNP group. Similarly, the adjusted hazard ratio for 2\u2010year all\u2010cause mortality was 1.51 (95% CI 0.91\u20132.50) for those in the moderate NT\u2010proBNP group and 2.66 (95% CI 1.63\u20134.32) for those in the high NT\u2010proBNP group. Higher pre\u2010operative NT\u2010proBNP levels were associated with an increased risk for postoperative complications and 2\u2010year all\u2010cause mortality (both\n                      <jats:italic>p<\/jats:italic>\n                      for trend &lt;\u20090.001) among hip fracture patients. The results were consistent across various subgroup and sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative NT\u2010proBNP is strongly associated with both postoperative complications and 2\u2010year all\u2010cause mortality among patients received hip fracture surgery. Higher levels of NT\u2010proBNP before surgery may serve as a useful biomarker for risk stratification and guiding treatment decisions for this patient subpopulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/os.70243","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:10:56Z","timestamp":1768489856000},"page":"368-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>NT<\/scp>\n                    \u2010\n                    <scp>proBNP<\/scp>\n                    With Postoperative Complications and 2\u2010Year Mortality Among Hip Fracture Patients: An Observational Cohort Study"],"prefix":"10.1111","volume":"18","author":[{"given":"Xisheng","family":"Lin","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Department of Rehabilitation Medicine, The Second Medical Center &amp; National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhuai","family":"Tan","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houchen","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-1749","authenticated-orcid":false,"given":"Licheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.51"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-022-06690-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003180"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8040"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.50"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S291071"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.033"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029110"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-13-97"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11331"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep139"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5245-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009416"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-023-01295-x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000614"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S404211"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2597"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2024.105695"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-021-05091-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npab049"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2505-7"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521288"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-023-06949-y"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-2501"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390507"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1558"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.8.879"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.932996"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042330"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.873265"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0800239"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17636-0"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6664"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03752-w"},{"issue":"3","key":"e_1_2_12_37_1","first-page":"215","article-title":"Association Between Preoperative High Sensitive Troponin I Levels and Cardiovascular Events After Hip Fracture Surgery in the Elderly","volume":"15","author":"Kim B. 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