{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:59:01Z","timestamp":1773021541692,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although advances in disease\u2010modifying therapies have improved rheumatoid arthritis (RA) management, many patients still require total hip or knee arthroplasty. Long\u2010term data on baseline characteristics and treatment patterns of RA patients undergoing arthroplasty in China are scarce. This study aimed to investigate time trends in baseline demographic, clinical, laboratory, and treatment parameters of RA patients undergoing THA and TKA between 2002 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of consecutive THAs and TKAs for RA patients between 2002 and 2022 was conducted at a single center. The preoperative patient demographics, clinical and laboratory parameters were collected. All joints were divided into 2002\u20132011 and 2012\u20132022 groups, THA and TKA groups, juvenile\u2010onset rheumatoid arthritis (JORA) (0\u201316\u2009years), adult\u2010onset rheumatoid arthritis (AORA) (16\u201360\u2009years), and late\u2010onset rheumatoid arthritis (LORA) (\u2265\u200960\u2009years) groups, respectively. The intergroup comparisons were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1363 primary TKAs in 897 patients with RA and 561 hips in 511 patients with RA were included. The number of arthroplasties performed annually from 2002 to 2022 demonstrated a significantly increasing trend. The use of glucocorticoids (GCs) before surgery demonstrated a significant decreasing trend while conventional synthetic disease\u2010modifying anti\u2010rheumatic drugs (csDMARDs) and biological DMARDs (bDMARDs)\u2009+\u2009targeted synthetic DMARDs (tsDMARDs) demonstrated an increasing trend. Comparison by time period (2002\u20132011 vs. 2012\u20132022) showed that the percentage of preoperative use of csDMARDs and bDMARDs\u2009+\u2009tsDMARDs was significantly higher and GCs were significantly higher in the 2002\u20132011 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The number of THAs and TKAs performed annually from 2002 to 2022 demonstrated a significantly increasing trend in a tertiary care center for musculoskeletal diseases. In contrast, a significantly increasing trend for the percentage of preoperative use of csDMARDs and bDMARDs\u2009+\u2009tsDMARDs and a significantly decreasing trend for preoperative use of GCs and inflammatory markers was identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/os.70252","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:01:02Z","timestamp":1769558462000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolving Characteristics of Rheumatoid Arthritis Patients Receiving Primary Hip or Knee Arthroplasty: A 21\u2010Year Single\u2010Center Trend Analysis (2002\u20132022)"],"prefix":"10.1111","volume":"18","author":[{"given":"Xingshan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-2735","authenticated-orcid":false,"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siliang","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u201000816\u2010x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.301223.eaf"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15839"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rai2.12043"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020323"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170001"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1812794"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2019.1649111"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.12788\/ajo.2018.0050"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-2025-0071"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-011-1432-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20210817-01"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150525"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.06.002"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22628"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3328"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141297"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-9-146"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170046"},{"issue":"5","key":"e_1_2_12_23_1","first-page":"836","article-title":"Chinese Registry of Rheumatoid Arthritis (CREDIT): I. 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