{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:44:24Z","timestamp":1775616264207,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014882","name":"Department of Finance of Hebei","doi-asserted-by":"publisher","award":["ZF2024075"],"award-info":[{"award-number":["ZF2024075"]}],"id":[{"id":"10.13039\/501100014882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hip fracture is a severe injury in the elderly population and can trigger a strong physiologic stress reaction with potential impact on clinical outcomes. However, few data are available on the temporal evolution of hematologic parameters after this injury. This study aimed to evaluate the temporal trends of key hematological and inflammatory\u2010immune markers in elderly patients with hip fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted among elderly patients with hip fractures managed at a tertiary referral center from January 2022 to October 2024. Included patients were required to have both complete serial hematological measurements obtained during the first 5\u2009days post\u2010fracture and relevant clinical data. We used generalized estimating equation models for repeated measurements to describe the temporal trends of key hematological markers, with analyses stratified by fracture type and age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of sixty patients were included, with a mean age of 80\u2009\u00b1\u20097.4\u2009years (range: 65\u201396\u2009years) and 68.3% females (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941). Within the first 1\u20135\u2009days post\u2010fracture, hemoglobin decreased by a mean of 9.66\u2009g\/L, hematocrit by 3.10 percentage points, neutrophil percentage by 8.12 percentage points, neutrophil count by a mean of 2.41\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, and neutrophil\u2010to\u2010lymphocyte ratio (NLR) by 3.07 (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values &lt;\u20090.001). Conversely, lymphocyte and monocyte counts exhibited a biphasic change, peaking on day 4 prior to subsequent decline. Subgroup analyses revealed that monocyte levels demonstrated significant interactions between time and fracture type (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036), whereas both lymphocytes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) and monocytes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) exhibited significant interactions between age and time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hemoglobin, hematocrit, neutrophil percentage, neutrophil count, and NLR progressively decrease during days 1\u20135 after hip fracture in older patients, whereas lymphocyte and monocyte counts exhibit biphasic patterns and vary significantly according to fracture type and age. These findings may help clinicians in interpreting early post\u2010fracture laboratory dynamics and provide a basis for future outcome\u2010oriented validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/os.70288","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:34:14Z","timestamp":1773934454000},"page":"835-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Changes in Key Hematological and Inflammatory\u2010Immune Markers Among Elderly Patients Following Hip Fracture: A Five\u2010Day Serial Assessment"],"prefix":"10.1111","volume":"18","author":[{"given":"Yuening","family":"Han","sequence":"first","affiliation":[{"name":"Economic Development Institute of Nankai University Nankai University  Tianjin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinqun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"},{"name":"Hebei Orthopaedic Research Institute Key Laboratory of Biomechanics of Hebei Province, Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengsi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"},{"name":"Hebei Orthopaedic Research Institute Key Laboratory of Biomechanics of Hebei Province, Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"},{"name":"Hebei Orthopaedic Research Institute Key Laboratory of Biomechanics of Hebei Province, Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4156-0710","authenticated-orcid":false,"given":"Cici","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hebei Medical University Third Hospital  Shijiazhuang Hebei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2021.100348"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12368"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.12.015"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-023-00380-6"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12155147"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S120526"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.13932"},{"issue":"9","key":"e_1_2_14_9_1","article-title":"Admission Hemoglobin Associated With Increased Mortality in Hip Fracture Surgical Patients: An Observational Study","volume":"12","author":"\u0160ari\u0107 Jadrijev A.","year":"2024","journal-title":"Biomedicine"},{"issue":"1","key":"e_1_2_14_10_1","first-page":"71","article-title":"Admission Neutrophile to Lymphocyte Ratio and Postoperative Mortality in Elderly Hip Fracture Patients","volume":"25","author":"Temiz A.","year":"2019","journal-title":"Turkish Journal of Trauma and Emergency Surgery"},{"issue":"14","key":"e_1_2_14_11_1","first-page":"1196","article-title":"The American Academy of Orthopaedic Surgeons Evidence\u2010Based Guideline on Management of Hip Fractures in the Elderly","volume":"97","author":"Brox W. 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G.","year":"2005","journal-title":"Journal of Bone and Joint Surgery\u2010American Volume"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90129-5"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23462"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-014-0667-3"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.02.015"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.07.239"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2536OC"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.10.027"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245815"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14300"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-024-00413-8"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.003186"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-017-0413-9"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101837"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.938075"},{"issue":"4","key":"e_1_2_14_28_1","article-title":"Changes of the Blood Lymphocytes on Severe Trauma Patients in Early Time: A Retrospective Cohort Study","volume":"11","author":"Cao F.","year":"2023","journal-title":"Angiolgy Open Access"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-025-02864-0"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.70288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.70288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.70288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:51:58Z","timestamp":1775613118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.70288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/os.70288"],"URL":"https:\/\/doi.org\/10.1111\/os.70288","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}