{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:10:02Z","timestamp":1780387802457,"version":"3.54.1"},"reference-count":78,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cervical degenerative disc disease (DDD) occurs when there is deterioration of the intervertebral discs in the cervical spine and can cause extreme pain and disability. Cervical disc arthroplasty (CDA) and anterior cervical discectomy and fusion (ACDF) are the two prominent surgical treatment options. There are a few meta\u2010analyses that examine the cost\u2010effectiveness of these two methods. This meta\u2010analysis study seeks to provide a thorough overview of cost\u2010effectiveness and postoperative complications between CDA and ACDF in the treatment of cervical DDD. Publication search was carried out on PubMed and Embase up until March 2025. Comparison studies that included the two treatment methods of interest and reported a cost analysis with complication metrics were included in this meta\u2010analysis. Review Manager 5.4. was utilized for statistical analyses, and a\n                    <jats:italic>p<\/jats:italic>\n                    value \u2264\u20090.05 was considered statistically significant. Thirteen studies were included. Regarding the cost analysis, there was a significant difference in initial cost in favor of ACDF compared to CDA. As for the outcome metrics, there was a significant difference in reoperation as well as DVT\/PE rates in favor of CDA. There was a significant difference in mean operative time in favor of ACDF. No other significant differences were found. ACDF appears to be a cost\u2010effective option, while CDA offers advantages in certain complication metrics. Additional studies investigating the relationship between treatment costs and complications should be completed in order to solidify the superior treatment method for cervical DDD.\n                  <\/jats:p>","DOI":"10.1111\/os.70306","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:44:41Z","timestamp":1774946681000},"page":"1133-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Meta\u2010Analysis of Cost\u2010Effectiveness in Cervical Degenerative Disc Disease Treated With Cervical Disc Arthroplasty Versus Anterior Cervical Discectomy and Fusion"],"prefix":"10.1111","volume":"18","author":[{"given":"Thomas","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Devgan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun U.","family":"Jayatissa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Elgafy","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-8276","authenticated-orcid":false,"given":"Jiayong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Cervical Degenerative Disc Disease","author":"Fakhoury J.","year":"2025"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.74418"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12020253"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.09.019"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2019.73.421\u2010424"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"74","article-title":"Nonoperative Management of Degenerative Cervical Radiculopathy: Protocol of a Systematic Review","volume":"66","author":"Plener J.","year":"2022","journal-title":"Journal of the Canadian Chiropractic Association"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aorn.13329"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0000000000001406"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14186559"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2023.12.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002665"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568217726283"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.10.SPINE15505"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_12_17_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta\u2010 Analyses","author":"Wells G. 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