{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:15:38Z","timestamp":1783016138058,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Scaphoid nonunion remains a challenging problem due to limited vascularity and carpal malalignment. Although autologous bone grafting remains the standard of care, donor\u2010site morbidity and technical demands can be substantial. NOVOSIS, a composite of recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) and a hydroxyapatite (HA) carrier, has shown osteoinductive and osteoconductive potential in other orthopedic applications, but its clinical efficacy in scaphoid nonunion has not been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven consecutive patients with scaphoid waist nonunion underwent fixation using two 2.3\u2010mm headless compression screws and NOVOSIS application between August 2023 and December 2024. All patients were followed for a minimum of 12\u2009months (mean 12.4\u2009months; range 12\u201314). Clinical outcomes were assessed using visual analogue scale (VAS), range of motion (ROM), and Mayo Wrist Score (MWS). Radiographic parameters included lateral intrascaphoid angle (LISA) and scapholunate angle (SLA). Paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests compared pre\u2010 and postoperative values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients achieved radiographic union at final follow\u2010up. VAS scores improved from 4.9\u2009\u00b1\u20091.2 to 0.4\u2009\u00b1\u20090.8 (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001), and MWS from 59.3\u2009\u00b1\u20097.3 to 94.3\u2009\u00b1\u20095.4 (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001). LISA improved from 51.7\u00b0\u2009\u00b1\u200913.6\u00b0 to 31.5\u00b0\u2009\u00b1\u20095.1\u00b0 (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.007), and SLA from 65.7\u00b0\u2009\u00b1\u20096.8\u00b0 to 52.2\u00b0\u2009\u00b1\u20098.8\u00b0 (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.006). No procedure\u2010related complications, such as infection, ectopic bone formation, or donor\u2010site morbidity, were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This preliminary clinical series demonstrated that NOVOSIS provided reliable union, functional recovery, and radiographic correction in scaphoid nonunion without donor\u2010site morbidity. It may serve as a feasible alternative to autologous bone grafting and warrants further validation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/os.70347","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:40:22Z","timestamp":1780717222000},"page":"1350-1358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Radiologic Outcomes of\n                    <scp>NOVOSIS<\/scp>\n                    (\n                    <scp>rhBMP<\/scp>\n                    \u20102 With Hydroxyapatite Carrier) Grafting for Scaphoid Waist Nonunion: A Preliminary Clinical Study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-0215","authenticated-orcid":false,"given":"Jisu","family":"Park","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Wonju College of Medicine Yonsei University, Wonju Severance Christian Hospital  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Youn","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Wonju College of Medicine Yonsei University, Wonju Severance Christian Hospital  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Joon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Wonju College of Medicine Yonsei University, Wonju Severance Christian Hospital  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Rok","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Wonju College of Medicine Yonsei University, Wonju Severance Christian Hospital  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2008.04.026"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2022.05.006"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00453208"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(80)80087-6"},{"key":"e_1_2_14_6_1","first-page":"759","article-title":"Fracture of the Carpal Navicular. 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