{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:53:01Z","timestamp":1785775981736,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902266"],"award-info":[{"award-number":["81902266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High\u2010grade isthmic spondylolisthesis remains surgically controversial, and evidence on minimally invasive, single\u2010level reduction and fusion with mid\u2010term follow\u2010up remains limited. This study aimed to investigate the efficacy and safety of minimally invasive transforaminal lumbar interbody fusion (MIS\u2010TLIF) and percutaneous pedicle screw fixation for high\u2010grade (Meyerding Grade III) spondylolisthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective observational case series included 14 consecutive patients with Meyerding Grade III isthmic spondylolisthesis treated at a single institution between 2014 and 2019. All patients underwent monosegmental MIS\u2010TLIF with percutaneous pedicle screw fixation. Outcome measures included VAS (back and leg pain), ODI, slip percentage, Dubousset lumbosacral angle, and other spinopelvic parameters. Pre\u2010 and postoperative comparisons were performed using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen patients had a mean age of 54.9\u2009years with a diagnosis of isthmic spondylolisthesis, Meyerding Grade III. The average estimated blood loss was 273.93\u2009mL (range, 197\u2013380\u2009mL). The average operating time was 142.14\u2009min (range, 125\u2013165\u2009min). The average follow\u2010up duration was 43.5\u2009months, with a range of 38\u201360\u2009months. In most cases, radicular pain was significantly relieved postoperatively. The mean ODI scores decreased from preoperative 65.56% to postoperative 7.93%. All cases achieved near\u2010anatomic reduction, and lumbosacral lordosis was significantly corrected. The average slip percentage improved from 64.36% (preop) to 5.88% (postop), and the average Dubousset\u2010LSA increased from 81.96\u00b0 (preop) to 105.93\u00b0 (postop). The overall sagittal profile improved dramatically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MIS\u2010TLIF and percutaneous pedicle screw fixation may offer a safe and effective treatment option for high\u2010grade spondylolisthesis, with satisfactory clinical and radiological outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/os.70364","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:11:02Z","timestamp":1783469462000},"page":"1591-1600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Radiological Outcomes of Monosegmental Minimally Invasive Transforaminal Lumbar Interbody Fusion for High\u2010Grade Spondylolisthesis: A 3\u2010Year Observational Study"],"prefix":"10.1111","volume":"18","author":[{"given":"Chao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Surgery, Xinqiao Hospital Army Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Xinqiao Hospital Army Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-0798","authenticated-orcid":false,"given":"Changqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Xinqiao Hospital Army Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-6116","authenticated-orcid":false,"given":"Piming","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery, Xinqiao Hospital Army Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001433-200206000-00004"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(26)01365-0"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198512000-00013"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001238"},{"key":"e_1_2_14_6_1","first-page":"512","article-title":"Uninstrumented In\u00a0Situ Fusion for High\u2010Grade Childhood and Adolescent Isthmic Spondylolisthesis: Long\u2010Term Outcome","volume":"89","author":"Lamberg T.","year":"2007","journal-title":"Journal of Bone and Joint Surgery. American Volume"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.14444\/2050"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-017-5345-7"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e318149e7ea"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bsd.0000132291.50455.d0"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200011150-00017"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181c3e740"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005860050038"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199704000-00010"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200209150-00011"},{"issue":"19","key":"e_1_2_14_16_1","article-title":"Evidence\u2010Based Medicine Analysis of Isthmic Spondylolisthesis Treatment Including Reduction Versus Fusion In\u00a0Situ for High\u2010Grade Slips","volume":"32","author":"Transfeldt E. E.","year":"2007","journal-title":"Spine"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31814b2cee"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-011-1932-1"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-019-05973-8"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-019-05954-x"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2018.03.006"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000138279.53439.cc"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31821cc558"},{"issue":"8","key":"e_1_2_14_24_1","first-page":"679","article-title":"The Relationship Between the Extent of Reduction and the Change of Spino\u2010Pelvic Parameters in High Dysplastic Developmental Spondylolisthesis","volume":"30","author":"Guo X.","year":"2020","journal-title":"Chinese Journal of Spine and Spinal Cord"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000197204.91891.eb"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2623-2"},{"issue":"2","key":"e_1_2_14_27_1","article-title":"Complete Anatomic Reduction and Monosegmental Fusion for Lumbar Spondylolisthesis of Grade II and Higher: Use of the Minimally Invasive \u201cRocking\u201d Technique","volume":"43","author":"Deshpande V.","year":"2017","journal-title":"Neurosurgical Focus"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-010-1404-z"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000155583.55856.f9"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3171\/2021.3.SPINE202091"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3182535881"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23533"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2190-6"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.02.035"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.70364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.70364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.70364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:25:59Z","timestamp":1785774359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.70364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/os.70364"],"URL":"https:\/\/doi.org\/10.1111\/os.70364","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2026-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}