{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:26Z","timestamp":1787015846294,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inappropriate sinus tachycardia (IST) occurs relatively common after catheter ablation of slow pathway in patients with atrioventricular nodal reentrant tachycardia. The treatment of IST symptoms using \u03b2\u2010blockers or calcium channel\u2010blockers are often noneffective or not well tolerated. Ivabradine is a new heart rate (HR)\u2010decreasing agent inhibiting sinus node If current. The purpose of the study was to evaluate the efficacy and safety of ivabradine in patients with persistent and \u03b2\u2010blocker\u2010resistant IST after successful radiofrequency (RF) ablation of atrioventricular node slow pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 14 patients (42 \u00b1 11 years; 10 women) affected by IST after RF ablation. Holter monitoring, treadmill stress test, and IST symptoms assessment were performed at baseline and after first, and second month of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed significant reduction of mean resting HR after 30 and 60 days of ivabradine treatment compared to baseline (P &lt; 0.001). 24\u2010hour Holter monitoring showed a significant reduction of mean HR and mean HR during daily activity (P &lt; 0.001). The study revealed significant improvement in exercise capacity during treadmill exercise test on ivabradine therapy (P &lt; 0.001). Significantly lower incidence of IST\u2010related symptoms were registered after administration of If current inhibitor. After 2 months of treatment no patients reported severe complaints assessed by means of European Heart Rhythm Association score. We did not observe severe side effects during therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ivabradine is an effective treatment option to reduce HR and symptoms in patients with IST after RF ablation of atrioventricular node slow pathway. The therapy with ivabradine is well tolerated even with maximum daily dose.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>(PACE 2013; 36:42\u201349)<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.12018","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T20:34:40Z","timestamp":1350592480000},"page":"42-49","source":"Crossref","is-referenced-by-count":22,"title":["Ivabradine in the Treatment of Inappropriate Sinus Tachycardia in Patients after Successful Radiofrequency Catheter Ablation of Atrioventricular Node Slow Pathway"],"prefix":"10.1111","volume":"36","author":[{"given":"PAWEL","family":"PTASZYNSKI","sequence":"first","affiliation":[{"name":"Department of Electrocardiology Chair of Cardiology and Cardiosurgery Medical University  Lodz 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