{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:52:22Z","timestamp":1760863942001},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence, predictors, and survival for the development of pacemaker dependence (PD) in patients implanted with an implantable cardioverter defibrillator (ICD) are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of 1,550 consecutive patients with ICD implantation at a single center from 1996 to 2008 with a mean of 4.2 \u00b1 3.4 years. Patients with implant intrinsic heart rates less than 40 beats\/min (n = 48) and cardiac resynchronization therapy (n = 444) were excluded leaving 1,058 patients in this study. PD was defined as an intrinsic rhythm &lt;40 beats\/min after inhibiting the pacemaker, &lt;50 beats\/min with transient symptoms of dizziness relieved by resumption of pacing and right ventricle pacing despite algorithms to promote intrinsic conduction at the 3 monthly follow\u2010up ICD clinic visits. Multivariate regression and Cox proportional hazard models were used for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 64 \u00b1 13 years; 79% were male with a primary indication for the ICD in 57%. PD occurred in 142 (13.4%) of patients, with a mean time to PD of 2.6 \u00b1 1.9 years. PD was associated with a 48% increased odds for mortality versus non\u2010PD ICD patients during the mean follow\u2010up time of 4.2 \u00b1 3.4 years (adjusted odds ratio = 1.48 [95% confidence interval 1.080\u20132.042]; P = 0.015). Older age, a history of atrial fibrillation, amiodarone use, and secondary prevention were the strongest predictors for the development of PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this single\u2010center ICD cohort, the development of PD was not uncommon and was associated with decreased survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12164","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T15:10:21Z","timestamp":1368457821000},"page":"945-951","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Pacemaker Dependence and Pacemaker Dependence as a Predictor of Mortality in Patients with Implantable Cardioverter Defibrillator"],"prefix":"10.1111","volume":"36","author":[{"given":"NITESH","family":"SOOD","sequence":"first","affiliation":[{"name":"Division of Cardiology Lahey Clinic  Burlington Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIC","family":"CRESPO","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hartford Hospital; University of Connecticut School of Medicine  Hartford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEIR","family":"FRIEDMAN","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hartford Hospital; University of Connecticut School of Medicine  Hartford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANETTE","family":"GUERTIN","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hartford Hospital; University of Connecticut School of Medicine  Hartford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"ZWEIBEL","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hartford Hospital; University of Connecticut School of Medicine  Hartford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEFFREY","family":"KLUGER","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hartford Hospital; University of Connecticut School of Medicine  Hartford Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER A.","family":"CLYNE","sequence":"additional","affiliation":[{"name":"Division of Cardiology Southcoast Health System  Fall River Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612263352601"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372202"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912163412503"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2005.00073.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.25.3081"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00466.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup195"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.10.035"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.24.3115"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.07.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.05.038"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.629428"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.057"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03425-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381602"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072769.17295.B1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.061"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr085"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.12164","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.12164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:54:19Z","timestamp":1696236859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.12164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,13]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/pace.12164"],"URL":"https:\/\/doi.org\/10.1111\/pace.12164","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,13]]}}}