{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:11:37Z","timestamp":1696309897407},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>High irrigation rates during radiofrequency (RF) ablation may cause fluid overload and limit lesion size. This in vivo animal study assessed the safety and efficacy of RF ablation at low irrigation rates using a novel 12\u2010hole gold catheter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 103 lesions, created on the thigh of five mongrel dogs, were analyzed. Lesions were created using a 12\u2010hole irrigated gold\u2010tip (Au) and a six\u2010hole irrigated platinum\u2013iridium (PtIr) catheter (both 7F\/3.5\u2010mm electrode; BIOTRONIK SE &amp; CO, KG, Berlin, Germany) in parallel and perpendicular orientation. RF current was delivered for 60 seconds at 30 W using 8\u00a0mL\/min and 15\u00a0mL\/min irrigation. Electrode temperature, steam pops, lesion dimensions, and coagulum formation were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Electrode temperatures were lower for Au compared to PtIr in parallel (8\u00a0mL\/min: 38.1\u00a0\u00b1 1.7\u00b0C vs 48.0\u00a0\u00b1 4.8\u00b0C, P &lt; 0.0001; 15\u00a0mL\/min: 36.0\u00a0\u00b1 1.5\u00b0C vs 46.9\u00a0\u00b1 5.4\u00b0C, P &lt; 0.0001) and perpendicular position (15\u00a0mL\/min: 35.5\u00a0\u00b1 1.2\u00b0C vs 38.4\u00a0\u00b1 2.5\u00b0C, P\u00a0= 0.003). The number of steam pops between Au and PtIr was comparable for parallel (8\u00a0mL\/min: 14% vs 27%, P\u00a0= 0.65; 15\u00a0mL\/min: 14% vs 43%, P\u00a0= 0.21) and perpendicular orientation (8\u00a0mL\/min: 25% vs 17%, P\u00a0= 1.00; 15\u00a0mL\/min: 18% vs 0%, P\u00a0= 0.48). Au created larger volumes than PtIr at 8\u00a0mL\/min irrigation (861\u00a0\u00b1 251\u00a0mm<jats:sup>3<\/jats:sup> vs 504\u00a0\u00b1 212\u00a0mm<jats:sup>3<\/jats:sup>, P\u00a0= 0.004); however, for 15\u00a0mL\/min, volumes were comparable (624\u00a0\u00b1 269\u00a0mm<jats:sup>3<\/jats:sup> vs 768\u00a0\u00b1 466\u00a0mm<jats:sup>3<\/jats:sup>, P\u00a0= 0.46). No coagulum formation was observed for any of the catheters on the surface and catheter tip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RF ablation at low flow rate using a novel 12\u2010hole irrigation Au catheter is safe and results in larger lesions than with a PtIr electrode.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12215","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T19:50:42Z","timestamp":1374522642000},"page":"1373-1381","source":"Crossref","is-referenced-by-count":3,"title":["Radiofrequency Ablation at Low Irrigation Flow Rates Using a Novel 12\u2010Hole Gold Open\u2010Irrigation Catheter"],"prefix":"10.1111","volume":"36","author":[{"given":"FERDI","family":"AKCA","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ENDRE","family":"ZIMA","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ESZTER M.","family":"V\u00c9GH","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00c1BOR","family":"SZ\u00c9PLAKI","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUDIT","family":"SKOP\u00c1L","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"HUBAY","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZSUZSANNA","family":"LENDVAI","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BELA","family":"MERKELY","sequence":"additional","affiliation":[{"name":"Department of Cardiology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAMAS","family":"SZILI\u2010TOROK","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Erasmus Medical Center  Rotterdam the 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