{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:37:08Z","timestamp":1771263428251,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vasovagal syncope (VVS) is characterized by a wide spectrum of clinical presentations, but the relationship between clinical presentation and response to head\u2010up tilt testing (HUT) has not yet been evaluated in detail. The aim of this study was to assess the relationship between the clinical presentation of VVS and HUT and clinical outcome at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Out of 671 consecutive subjects undergoing nitroglycerin\u2010potentiated HUT for suspected VVS, 369 patients with normal electrocardiogram and no structural heart disease were included in our study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A history suggestive of typical or atypical VVS was obtained in 198 and 171 patients, respectively. The positivity rate of HUT was 65% and 36% in patients with established and likely VVS, respectively (P &lt; 0.0001). In patients with established VVS, a time interval of \u226428 days between the last syncope and HUT was the only independent predictor of a positive test. In patients with likely VVS, no variable was predictive of a positive HUT. At a mean follow\u2010up of 43 \u00b1 27 months, the rate of adverse events (all\u2010cause mortality, syncope recurrence, and major diagnostic and\/or therapeutic procedures) was similar in patients of both groups, independent of HUT results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with likely VVS, HUT has a low\u2010diagnostic yield and may be inadequate to establish a reliable diagnosis. Similar long\u2010term outcomes were observed in patients with positive or negative test results, suggesting that HUT is of limited value in the management of patients with suspected neurally mediated syncope.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12235","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T21:19:58Z","timestamp":1377897598000},"page":"164-172","source":"Crossref","is-referenced-by-count":21,"title":["Nitrate\u2010Potentiated Head\u2010Up Tilt Testing (HUT) Has a Low Diagnostic Yield in Patients with Likely Vasovagal Syncope"],"prefix":"10.1111","volume":"37","author":[{"given":"NUNZIA R.","family":"PETIX","sequence":"first","affiliation":[{"name":"Arrhythmology Section \u2013 Cardiology Department San Giuseppe Hospital  Empoli (FI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATTILIO","family":"DEL ROSSO","sequence":"additional","affiliation":[{"name":"Arrhythmology Section \u2013 Cardiology Department 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