{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:53:25Z","timestamp":1791608005399,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pacing the right ventricle is established practice, but there remains controversy as to the optimal site to preserve hemodynamic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate clinical and hemodynamic differences between apical and septal pacing in pacemaker\u2010dependent patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients receiving their first pacemaker for advanced atrioventricular block, with the atria in sinus rhythm, were randomized to receive apical (Group A) or septal (Group S) ventricular leads. After implant, with the device programmed VVI 70 beats\/min fixed rate, patients underwent a 6\u2010minute walk test and a transthoracic echocardiogram. Then, DDDR was programmed at nominal settings. The same tests were performed at 6 months and 12 months follow\u2010up. If ventricular pacing was less than 98%, the patient was excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 142 patients were included in the study. During the study year, 71 (50%) were excluded for not fulfilling the condition of 98% ventricular pacing. Groups A and S had 34 and 37 patients, respectively. Age and gender were similar in the groups. At implant, QRS duration was significantly greater in Group A (158 ms) than Group S (146 ms; P = 0.018), and the QRS axis was different: \u201374.5\u00b0 in Group A and 1\u00b0 in Group S (P &lt; 0.001). At 1 year, the 6\u2010minute walk improved significantly in both groups: Group A 15% (P = 0.048) and Group S 24% (P = 0.001). Left ventricular ejection fraction (LVEF) increased from 0.57 to 0.61 (P = 0.008) in Group S, without significant change in Group A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After 1 year, pacemaker\u2010dependent patients with septal ventricular leads have better clinical and functional (LVEF) outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12257","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T19:27:13Z","timestamp":1378150033000},"page":"207-214","source":"Crossref","is-referenced-by-count":45,"title":["Medium\u2010Term Effects of Septal and Apical Pacing in Pacemaker\u2010Dependent Patients: A Double\u2010Blind Prospective Randomized Study"],"prefix":"10.1111","volume":"37","author":[{"given":"LUIS","family":"MOLINA","sequence":"first","affiliation":[{"name":"Arrhythmia Laboratory of the Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) en Hospital General de M\u00e9xico  Mexico City 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