{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:13:47Z","timestamp":1771978427812,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although several studies have demonstrated deleterious consequences of chronic right ventricular (RV) pacing on ventricular function and synchronicity, its effects on health\u2010related quality of life (HRQoL) and functional exercise capacity remain uncertain. We aimed to evaluate the effect of RV pacing on HRQoL and functional capacity of children and young adults with congenital complete atrioventricular block (CCAVB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>We included 66 consecutive subjects with RV cardiac pacemaker due to CCAVB and under clinical follow\u2010up for more than 1 year. Multidimensional HRQoL scores were evaluated by Short Form\u201036 Health Survey (SF\u201036) and Child Health Questionnaire\u2010Parent Form 50 (CHQ\u2010PF50). Functional capacity was tested by a 6\u2010minute walk distance test (6MWDT). Association analysis was performed to examine if any demographic and clinical characteristics were associated with lower HRQoL scores and shorter distances at the 6MWDT<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Domains presenting lower HRQoL scores were vitality (64.0<\/jats:italic> \u00b1 <jats:italic>17.3), mental health (67.3<\/jats:italic> \u00b1 <jats:italic>8.0), role emotional (69.7<\/jats:italic> \u00b1 <jats:italic>35.8) in the SF\u201036 questionnaire; general health perceptions (61.3<\/jats:italic> \u00b1 <jats:italic>8.3), general behavior (61.9<\/jats:italic> \u00b1 <jats:italic>15.6), parental impact\u2014emotional (67.7<\/jats:italic> \u00b1 <jats:italic>28.7) in the CHQ\u2010PF50. Female gender (P = 0.009), left ventricular ejection fraction lower than 55% (P = 0.013), cardiovascular drugs (P = 0.003) were significantly associated with lower HRQoL scores. Average distance traveled during the 6MWDT was 539.8<\/jats:italic> \u00b1 <jats:italic>82.9 m. The 6MWDT showed significant association with age (P = 0.006) and cardiovascular drugs (P = 0.024)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Chronic RV pacing did not affect the HRQoL and physical capacity of pediatrics and young subjects. Female gender, ventricular function, and cardiovascular drugs were associated with lower HRQoL scores. Older subjects walked shorter distances in the 6MWDT, as well as subjects who were taking cardiovascular drugs<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12258","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:14:58Z","timestamp":1381544098000},"page":"1539-1549","source":"Crossref","is-referenced-by-count":8,"title":["Quality of Life and Functional Capacity after Long\u2010Term Right Ventricular Pacing in Pediatrics and Young Adults with Congenital Atrioventricular Block"],"prefix":"10.1111","volume":"36","author":[{"given":"K\u00c1TIA REGINA","family":"DA SILVA","sequence":"first","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham North Carolina"},{"name":"Department of Cardiovascular Surgery Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERTO","family":"COSTA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"ROBERTO M\u00c1RCIO","family":"DE OLIVEIRA","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIANNA SOBRAL","family":"LACERDA","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIANA I","family":"UN HUANG","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARINA BERTELLI","family":"ROSSI","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH SARTORI","family":"CREVELARI","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WAGNER TETSUJI","family":"TAMAKI","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTINO MARTINELLI","family":"FILHO","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Institute (InCor)\u2014Clinics Hospital of the University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICARDO","family":"PIETROBON","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"301","article-title":"Congenital complete atrioventricular block","volume":"24","author":"Kertesz NJ","year":"1997","journal-title":"Texas Heart Inst 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