{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:23:44Z","timestamp":1789453424226,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although left ventricular (LV) systolic dysfunction is known to occur in adults with repaired Tetralogy of Fallot (TOF), the effects of cardiac resynchronization therapy (CRT) are not well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively divided all patients with repaired TOF and impaired LV ejection fraction (LVEF \u2264 40%) undergoing CRT at our institution (n\u2009=\u200910) into two groups: de novo CRT (group A, n\u2009=\u20096) or upgrade from existing device (group B, n\u2009=\u20094). Echocardiograms were reviewed at baseline, medium\u2010term (&gt;6 months post\u2010CRT), and long\u2010term follow\u2010up. CRT response was defined as reduction in LV end\u2010systolic volume (LVESV) \u226515% at medium term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age at surgical repair was 13.1\u2009\u00b1\u200916.0 years, age at CRT was 44.4\u2009\u00b1\u200912.5 years, and baseline LVEF was 24.0\u2009\u00b1\u200910.5%. Group A demonstrated a preponderance of right ventricular (RV) conduction delay, whereas all patients in group B demonstrated RV pacing at baseline. At medium\u2010term follow\u2010up, patients in group A showed significant improvements in LVEF, LV end\u2010diastolic volume (LVEDV), and LVESV. Group B also demonstrated a significant improvement in LVEF with favorable trends in LV volumes. Of nine patients with complete data at medium term, eight showed evidence of CRT response. Average long\u2010term follow\u2010up was 53.4\u2009\u00b1\u200929.3 months. At long\u2010term follow\u2010up, LVEF, LVEDV, and LVESV remained numerically better than baseline, although the results were no longer significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult patients with repaired TOF and LV systolic dysfunction demonstrate significant medium\u2010term response to CRT, even among those with RV conduction delay. The long\u2010term impact of CRT in this population requires further characterization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12284","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T19:32:22Z","timestamp":1382729542000},"page":"321-328","source":"Crossref","is-referenced-by-count":26,"title":["Cardiac Resynchronization Therapy in Adult Patients with Repaired Tetralogy of Fallot and Left Ventricular Systolic Dysfunction"],"prefix":"10.1111","volume":"37","author":[{"given":"FAISAL M.","family":"MERCHANT","sequence":"first","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANESH","family":"KELLA","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WENDY M.","family":"BOOK","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONATHAN J.","family":"LANGBERG","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL S.","family":"LLOYD","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta 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