{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:42:51Z","timestamp":1696311771399},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Electrical reconnection of the pulmonary veins (PVs) plays a key role in the recurrence of atrial fibrillation (AF) after ablative treatment. This randomized controlled study tested the hypothesis that prolonged ablations, on areas that may be critical for left atrial (LA)\u2010PV conduction, can significantly reduce the rate of acute PV reconnection and AF recurrence<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Patients with paroxysmal AF were randomly assigned to either a control or an add\u2010on group. Ostial PV isolation (PVI) was performed by point\u2010to\u2010point RF ablation (irrigated tip, 30 Watts, 30 seconds). An ostial segment was assumed to be critical for LA\u2010PV connection if any of the following reactions occurred during RF application: (1) sudden delay of LA\u2010PV conduction, (2) change of activation sequence, and (3) PVI. In this case, RF application was prolonged from 30 seconds to 90 seconds in the add\u2010on group only<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>A total of 131 patients (58<\/jats:italic> \u00b1 <jats:italic>11 years, 47 female) were assigned to a control (n = 64) and an add\u2010on (n = 67) group. Ablation time was longer in the add\u2010on (48<\/jats:italic> \u00b1 <jats:italic>16 minutes vs 37<\/jats:italic> \u00b1 <jats:italic>15 minutes, P = 0.03). Acute PV reconnection was observed in 20 of 64 controls and in eight of 66 add\u2010on patients (31% vs 12%, P &lt; 0.001). During a follow\u2010up of 26 months, AF recurred in 33 of 64 controls and in 16 of 66 add\u2010on patients (52% vs 24%, P = 0.001) after a single ablation procedure<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Prolonged radiofrequency application on critical segments of LA\u2010PV connection is a safe and effective ablative strategy that significantly reduces acute PV reconnection and AF recurrence rates after a single ablation procedure for paroxysmal AF<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12304","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T01:45:52Z","timestamp":1385430352000},"page":"603-609","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged Ablation on Critical Segments of Pulmonary Vein Ostia in Paroxysmal Atrial Fibrillation: A Prospective Randomized Controlled Study"],"prefix":"10.1111","volume":"37","author":[{"given":"CHARALAMPOS","family":"KRIATSELIS","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Cardiology German Heart Institute  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"KAUFMANN","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology German Heart Institute  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOTIRIOS","family":"NEDIOS","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology German Heart Institute  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIN","family":"TANG","sequence":"additional","affiliation":[{"name":"Department of Arrhythmia Fuwai Hospital and Cardiovascular Institute Chinese Academy of Medical Science Peking Union Medical College  Beijing P. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIN\u2010HONG","family":"GERDS\u2010LI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology German Heart Institute  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ECKART","family":"FLECK","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology German Heart Institute  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946806"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.054"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00594.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/europace\/eun311","article-title":"A new approach for contrast\u2010enhanced x\u2010ray imaging of the left atrium and pulmonary veins for atrial fibrillation ablation: Rotational angiography during adenosine\u2010induced asystole","volume":"11","author":"Kriatselis C","year":"2009","journal-title":"Europace"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151289.73085.36"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00533.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.076"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00981.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.04031.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.04.011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01564.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0450"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02195.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.960138"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.05.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.10.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.10.003"},{"key":"e_1_2_9_19_1","first-page":"327","volume":"6","author":"Neuzil P","year":"2013","journal-title":"Electrical reconnection after pulmonary vein isolation is contingent on contact force during initial treatment: Results from the EFFICAS I study. 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