{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:45:40Z","timestamp":1696571140667},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Procainamide is known to prolong PR, QRS, and QTc intervals in adults and is utilized to unmask the distinct electrocardiographic signatures, including right bundle branch block pattern and right precordial ST segment elevation seen with Brugada syndrome. This study analyzes a pediatric case series of procainamide challenges done to evaluate for possible Brugada syndrome. Our goal was to quantify the impact of procainamide on electrocardiographic intervals in all pediatric patients, regardless of the eventual determination of Brugada syndrome status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed all children undergoing procainamide challenge, consecutively from March 2009 to September 2012. Patients received intravenous procainamide over 15\u00a0minutes. All electrocardiograms (ECGs) performed during the drug challenge were reviewed. Analysis and ECG measurements were performed by investigators blinded to clinical diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients undergoing procainamide infusion had prolongation of their PR (mean +14%; 0\u201345%), QRS (+13%; 2\u201349%), and QTc (+15%; 4\u201330%) intervals regardless of testing outcome. QTc prolongation to &gt;460\u00a0ms following procainamide infusion occurred in 76% of patients. No sustained arrhythmias or adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ECG changes including prolongation of the PR, QRS, and QTc intervals were seen in all children who underwent procainamide challenge for evaluation of possible Brugada syndrome. An increase in the PR, QRS, and QTc intervals of at least 20% occurred in all children without any adverse events. The QTc prolongation was not completely explained by the QRS prolongation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12402","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T08:58:39Z","timestamp":1400230719000},"page":"1106-1110","source":"Crossref","is-referenced-by-count":2,"title":["Universal ECG Changes in Pediatric Patients Undergoing Procainamide Challenge"],"prefix":"10.1111","volume":"37","author":[{"given":"CHRISTOPHER P.","family":"JORDAN","sequence":"first","affiliation":[{"name":"Division of Cardiology Children's National Medical Center  Washington D.C."},{"name":"Division of Cardiology Department of Pediatrics George Washington University School of Medicine  Washington D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHARLES I.","family":"BERUL","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's National Medical Center  Washington D.C."},{"name":"Division of Cardiology Department of Pediatrics George Washington University School of Medicine  Washington D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEFFREY P.","family":"MOAK","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's National Medical Center  Washington D.C."},{"name":"Division of Cardiology Department of Pediatrics George Washington University School of Medicine  Washington D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH ANNE","family":"GREENE","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's National Medical Center  Washington D.C."},{"name":"Division of Cardiology Department of Pediatrics George Washington University School of Medicine  Washington D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"45","volume-title":"Handbook of Experimental Pharmacology","author":"Williams EMV","year":"1989"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.02.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.5.510"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.03.061"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2000.01320.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.40564.x"},{"key":"e_1_2_6_9_1","unstructured":"VanHareGF.Antiarrhythmic drug dosages and preparations for children 2000\u20132001. Available at:http:\/\/peds.wustl.edu\/cardiology\/AntiarrhythmicDrugGuide\/tabid\/5462\/Default.aspx(accessed May 1 2014)."},{"key":"e_1_2_6_10_1","volume-title":"Drugs for the Heart","author":"Opie LH","year":"2009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.07.012"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.12402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.12402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:06:22Z","timestamp":1696471582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.12402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/pace.12402"],"URL":"https:\/\/doi.org\/10.1111\/pace.12402","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]}}}