{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:23:06Z","timestamp":1789903386891,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Boryung Pharmaceutical Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Premature ventricular complex (PVC) has been regarded as benign; however, when frequent, the arrhythmia can induce left ventricular (LV) systolic dysfunction. Meanwhile, the influence of PVCs on cardiac structural remodeling and functional change before occurrence of overt systolic heart failure has not been fully described. In this study, we attempted to identify early cardiac structural\/functional manifestations of frequent PVCs in patients with normal LV systolic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 146 patients (age: 55 \u00b1 15 years, 48 males) with frequent PVCs observed on 24\u2010hour Holter monitoring (&gt;10\/h) and normal LV ejection fraction (LV EF \u2265 55% on echocardiography) were enrolled. Clinical characteristics and echocardiographic parameters of the patients were compared with those of an age\u2010\/sex\u2010matched control group (n = 292, age: 55 \u00b1 15 years, 96 males).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with frequent PVCs had significantly larger left atrial volume index (LAVI [28 \u00b1 9 mL\/m<jats:sup>2<\/jats:sup> vs. 24 \u00b1 7 mL\/m<jats:sup>2<\/jats:sup>]), along with larger LV end\u2010diastolic dimension (49.4 \u00b1 4.4 mm vs. 48.5 \u00b1 3.9 mm), lower LV EF (63 \u00b1 7% vs. 66 \u00b1 6%), and lower peak systolic mitral annular velocity (7 \u00b1 2 cm\/s vs. 8 \u00b1 2 cm\/s; P &lt; 0.05 for all), whereas other clinical characteristics were similar. In particular, in patients with frequent PVCs, LAVI showed linear correlation with PVC burden (R = 0.30, P &lt; 0.001), and, in a multiple regression model, PVC burden independently estimated LAVI, even after controlling for age, sex, comorbidities, and systolic function (\u03b2 = 0.309, P &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Frequent PVC is associated with LA enlargement in patients with normal LV EF. Atrial anatomical remodeling may precede LV geometry change and systolic dysfunction in patients with frequent PVCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12447","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T04:54:22Z","timestamp":1405486462000},"page":"1455-1461","source":"Crossref","is-referenced-by-count":22,"title":["Frequent Premature Ventricular Complex Is Associated with Left Atrial Enlargement in Patients with Normal Left Ventricular Ejection Fraction"],"prefix":"10.1111","volume":"37","author":[{"given":"YEONJEONG","family":"PARK","sequence":"first","affiliation":[{"name":"Cardiology Division Department of Internal Medicine Gachon University of Medicine and Science  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUJI","family":"KIM","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Internal Medicine Gachon University of Medicine and Science  Incheon 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