{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:38:43Z","timestamp":1790419123447,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited and conflicting data regarding the prevalence of tricuspid regurgitation (TR) after cardiac device implantation (implantable cardioverter defibrillator [ICD]; permanent pacemaker [PPM]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to assess the prevalence of TR after cardiac device implantation and determine its clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,596 patients, who had cardiac devices implanted between 2005 and 2011 at the Cleveland Clinic and had at least one preimplantation echocardiogram and at least one postimplantation echocardiogram were included in this study. A total of 3,566 postimplantation echocardiograms were available for the 1,596 patients (median follow\u2010up 10 months). The primary end point was postimplantation TR and the secondary end point was all\u2010cause mortality after implantation. We have used a cumulative logistic nonlinear mixed\u2010effects model to assess the temporal trend of TR prevalence and a parametric multiphase hazard model to assess survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,596 patients (mean age: 60 \u00b1 10 years, 61% of patients were men), 985 (62%) had ICDs (including 334 patients with cardiac resynchronization therapy defibrillator) and 611 (38%) had PPMs. The prevalence of grade 3 or 4+ TR increased from 27% to 31% by 1 month and to 35% at 4 years. Accordingly, prevalence of grade 0\/1+ TR decreased from 46% preimplantation to 37% at 1 month and to 32% at 4 years. Device type (ICD vs PPM) and the number of leads placed did not have an effect on postimplantation TR (P &gt; 0.2). Right ventricular systolic pressure (RVSP) did not change over time (36 mm Hg baseline, 37.5 mm Hg by 3 months, and 37 mm Hg by 1 year). One\u2010year and 5\u2010year survival were 93% and 73%, respectively. Postimplantation TR was an independent risk factor for late death (P &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiac device implantation was associated with a small but significant increase in the prevalence of moderate and severe TR, both acutely and chronically after implantation. The increase in TR was similar with both ICD and PPM placement, which was not related to the number of leads implanted and not associated with a significant increase in RVSP. Postimplantation TR was associated with a higher risk of mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12530","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T08:37:57Z","timestamp":1415349477000},"page":"259-266","source":"Crossref","is-referenced-by-count":81,"title":["Tricuspid Regurgitation and Implantable Devices"],"prefix":"10.1111","volume":"38","author":[{"given":"RASHA","family":"AL\u2010BAWARDY","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMAR","family":"KRISHNASWAMY","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEEVANANTHAM","family":"RAJESWARAN","sequence":"additional","affiliation":[{"name":"Quantitative Health Sciences\/Division of Clinical Investigations Heart and Vascular Institute Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MANDEEP","family":"BHARGAVA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OUSSAMA","family":"WAZNI","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRUCE","family":"WILKOFF","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMIN MURAT","family":"TUZCU","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"MARTIN","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES","family":"THOMAS","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EUGENE","family":"BLACKSTONE","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAMIR","family":"KAPADIA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Foundation  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1540","volume":"60","author":"Grenspon AJ","year":"2012","journal-title":"Trends in permanent pacemaker implantation in the United States from 1993 to 2009: Increasing complexity of patients and procedures. 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