{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:57:43Z","timestamp":1762999063304,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) is frequently comorbid in patients receiving cardiac resynchronization therapy (CRT), and suppression is typically difficult. Herein, we sought to understand the benefit of atrial rhythm control in the setting of ventricular rate and regularity control induced by atrioventricular node (AVN) ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two patients with heart failure, persistent AF, left ventricular (LV) ejection fraction &lt;35%, and left bundle branch block underwent cardiac resynchronization therapy (CRT) + AVN ablation, and were randomized to one of the following groups: (1) Atrial Rhythm Control (ARC); (2) AF. Patients were subsequently followed for up to 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Similar numbers of patients in each group were lost to follow\u2010up or have withdrawn (ARC two; AF three). Rhythm control in four patients in the ARC group was inadequate. Among the remaining patients, the incidence of death (ARC=1, AF=2) or left ventricular assist device +\/\u2212 transplantation (ARC=2, AF=1) were similar. Among the remaining patients (ARC 16, AF 19), at 1 year, there were no significant differences in CRT response rate, Minnesota Living with Heart Failure survey score, 6\u2010minute hall walk distance, ventricular tachyarrhythmia occurrence, or LV dimensions. A significantly higher hospital encounter rate among ARC patients was attributable to efforts to maintain uniform atrial rhythm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this pilot study, no incremental benefit for ARC was apparent. A larger study will be necessary to adequately examine these issues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12535","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T15:39:00Z","timestamp":1417189140000},"page":"275-281","source":"Crossref","is-referenced-by-count":4,"title":["A Pilot Study to Assess Benefit of Atrial Rhythm Control after Cardiac Resynchronization Therapy and Atrioventricular Node Ablation"],"prefix":"10.1111","volume":"38","author":[{"given":"DAVID","family":"SCHWARTZMAN","sequence":"first","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEBRA","family":"HOUSEL","sequence":"additional","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAVEEN","family":"BAZAZ","sequence":"additional","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDEEP","family":"JAIN","sequence":"additional","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAMIR","family":"SABA","sequence":"additional","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"JOHN","family":"GORCSAN","sequence":"additional","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVAN","family":"ADELSTEIN","sequence":"additional","affiliation":[{"name":"Heart, Lung and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072767.89944.6E"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2004.07.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.891"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90986-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.02.014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.129429"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.043"},{"key":"e_1_2_5_9_1","first-page":"e6","article-title":"American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines; Heart Rhythm Society","volume":"61","author":"Epstein AE","year":"2013","journal-title":"2012 ACCF\/AHA\/HRS focused update incorporated into the ACCF\/AHA\/HRS 2008 guidelines for device\u2010based therapy of cardiac rhythm abnormalities: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. 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