{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:55:22Z","timestamp":1790373322860,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary vein isolation (PVI) causes a reduction in left atrium size that is attributable to reverse atrial remodeling (RAR). The objective of this study was to identify predictors of RAR and determine its association with other parameters of improvement in cardiac function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It is a prospective study with 74 patients (52\u00a0\u00b1\u00a09 years old, 81% male), and 51% of patients had paroxysmal atrial fibrillation. Patients were serially assessed with transthoracic echocardiography; plasma N\u2010terminal B\u2010type natriuretic peptide (NT\u2010proBNP); and high\u2010sensitivity C\u2010reactive protein levels at baseline and 3, 6, and 12 months following the PVI. RAR was defined as a reduction in the left atrial volume index (LAV\u2010index) &gt;10% from baseline at the end of follow\u2010up. A multivariate analysis was conducted to identify predictors of RAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LAV\u2010index decreased significantly during follow\u2010up in the entire population (P = 0.0005). RAR (experienced by 63.5% of the patients) was more frequent (76% vs. 42%; P = 0.004) and pronounced (reduction 16.65\u00a0\u00b1\u00a014% vs. 8\u00a0\u00b1\u00a014%; P = 0.015) in patients with a successful ablation (46 of 74 patients, 62.2%). Only patients with RAR showed significant improvement in NT\u2010proBNP levels (P = 0.0001), systolic function (P = 0.035), and diastolic function (P = 0.005). Multivariable analysis revealed that a successful ablation (odds ratio [OR] = 4.6; 95% confidence interval [CI] 1.46\u201314.68; P = 0.009), LAV\u2010index (OR = 1.15; 95% CI 1.03\u20131.2; P = 0.021), and patient's body mass index (OR = 0.84; 95% CI 0.74\u20130.96; P = 0.012) were independent predictors of RAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Successful PVI ablation is the main predictor of RAR that is associated with other parameters of improvement in cardiac function. The patient's body mass index may have a negative effect on RAR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12560","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T09:22:12Z","timestamp":1419326532000},"page":"216-224","source":"Crossref","is-referenced-by-count":14,"title":["Reverse Atrial Remodeling Following Pulmonary Vein Isolation: The Importance of the Body Mass Index"],"prefix":"10.1111","volume":"38","author":[{"given":"EDUARDO","family":"ARANA\u2010RUEDA","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALONSO","family":"PEDROTE","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LORENA","family":"GARC\u00cdA\u2010RIESCO","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALVARO","family":"ARCE\u2010LE\u00d3N","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FEDERICO","family":"G\u00d3MEZ\u2010PULIDO","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN\u2010MANUEL","family":"DUR\u00c1N\u2010GUERRERO","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AGUST\u00cdN","family":"FERN\u00c1NDEZ\u2010CISNAL","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MANUEL","family":"FRUTOS\u2010L\u00d3PEZ","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN\u2010ANTONIO","family":"S\u00c1NCHEZ\u2010BROTONS","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Hospital Universitario Virgen del Roc\u00edo  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.037"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.772582"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00258-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.048"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.484766"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.04407.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.07.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.04407.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.12.046"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12190"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Chamber Quantification Writing Group and American Society of Echocardiography's Guidelines. 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