{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:07:54Z","timestamp":1791828474575,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007405","name":"The Danish Heart Foundation","doi-asserted-by":"crossref","award":["14-R97-A5215-22870"],"award-info":[{"award-number":["14-R97-A5215-22870"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pacemakers (PMs) and implantable cardioverter defibrillators (ICDs) may develop malfunction during external beam radiotherapy (RT). We aimed to describe clinical practice in PM\/ICD patients undergoing RT and to assess the rate and predictors of device malfunctions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed medical records of all PM\/ICD patients undergoing RT at four centers in Western Denmark during 2003\u20132012. Logistic regression was applied to identify predictors of PM\/ICD malfunctions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five hundred sixty patients were included. The annual rate of RT courses in PM\/ICD patients increased by 199% from 1.45 treatments per 100,000 person\u2010years in 2003 to 4.33 in 2012. Safety measures included supplementary evaluations of PM\/ICD (38.3%), reprogramming (1.5%), relocation of the device (3.5%), and application of a magnet to the ICD during RT (10.8%). At device evaluations after the RT (n = 453), malfunctions were detected in 10 (2.5%) PMs and four (6.8%) ICDs. Electrical resets constituted 11 (78.6%) of the malfunctions, and no failures were life\u2010threatening or warranted PM\/ICD removal. Factors associated with device malfunctions in logistic regression analysis were beam energy \u226515 MV (odds ratio [OR] 5.73; 95% confidence interval [CI], 1.58\u201320.76) and location of tumor below the diaphragm (OR 4.31; 95% CI, 1.42\u201313.12). However, the effect of tumor location declined (OR 2.27; 95% CI, 0.65\u20137.95) after adjustment for beam energy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the rate of RT in PM\/ICD patients is increasing, the damaging effects of RT on the devices seem to be usually transient. Our data suggest that high beam energy plays the pivotal role in inducing impairments in these devices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.12572","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T03:22:46Z","timestamp":1421724166000},"page":"343-356","source":"Crossref","is-referenced-by-count":100,"title":["Risk of Device Malfunction in Cancer Patients with Implantable Cardiac Device Undergoing Radiotherapy: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"38","author":[{"given":"Tomas","family":"Zaremba","sequence":"first","affiliation":[{"name":"Department of Cardiology, Center for Cardiovascular Research Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNETTE ROSS","family":"JAKOBSEN","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Oncology Department Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"METTE","family":"S\u00d8GAARD","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Institute of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNA MARGRETHE","family":"TH\u00d8GERSEN","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Cardiovascular Research Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTIN BERG","family":"JOHANSEN","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University and Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00c6RKE BRUUN","family":"MADSEN","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Cardiovascular Research Aalborg University 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