{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:14:54Z","timestamp":1789924494347,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but highly malignant inherited arrhythmic disorder. Although a standardized exercise stress test (ST) is the most reliable way to diagnose CPVT, in 30% only single ventricular premature beats (VPCs) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether electrocardiographic characteristics of VPCs during ST distinguish patients with CPVT from healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electrocardiographic characteristics of VPCs during ST in 16 calsequestrin\u20102 (CASQ2) mutation carriers CPVT patients were compared with that in 36 healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CPVT patients had more VPCs (31\u00a0\u00b1\u00a014 vs 3\u00a0\u00b1\u00a04, P\u00a0&lt;\u00a00.0001), longer QRS duration (139\u00a0\u00b1\u00a018 ms vs 121\u00a0\u00b1\u00a021, P\u00a0=\u00a00.004), and coupling interval (CI; 476\u00a0\u00b1\u00a058 ms vs 355\u00a0\u00b1\u00a061 ms, P\u00a0&lt;\u00a00.0001). The most sensitive characteristics for CPVT were &gt;10 VPCs\/test (100% sensitivity, 100% negative predictive value [NPV]), left bundle branch block (LBBB) pattern with inferior axis (88% sensitivity, 94% NPV), and CI longer than 400 ms (88% sensitivity, 94% NPV). Bigeminy or trigeminy or LBBB pattern with inferior axis was most specific for CPVT at 100% (100% positive predictive value PPV, 92% NPV). First VPC during the recovery period and VPC recording more than 1 minute during the recovery period were most specific for healthy subjects (100% specificity, 100% PPV). In multivariate analysis, QRS duration &gt;120 ms (odds ratio 4.2, 95% confidence interval 1\u201317.6, P = 0.04) and first VPC at \u226510 mets (odds ratio 9.1, 95% confidence interval 2.01\u201341.1, P = 0.004) each predicted the presence of CPVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several electrocardiographic criteria can help distinguish VPCs originating from CPVT compared with healthy subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12574","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T08:51:40Z","timestamp":1422435100000},"page":"398-402","source":"Crossref","is-referenced-by-count":28,"title":["Electrocardiographic Comparison of Ventricular Premature Complexes during Exercise Test in Patients with CPVT and Healthy Subjects"],"prefix":"10.1111","volume":"38","author":[{"given":"MIRY","family":"BLICH","sequence":"first","affiliation":[{"name":"Division of Pacing and Electrophysiology Rambam 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