{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T22:12:22Z","timestamp":1758406342264,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL118277"],"award-info":[{"award-number":["HL118277"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In heart failure patients with implantable cardioverter defibrillator (ICD) the risk of death from causes other than tachyarrhythmia is substantial. Benefit from ICD is determined by two competing risks: appropriate ICD shock or nonarrhythmic death. The goal of the study was to test predictors of competing outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with structural heart disease (N = 234, mean age 58.5 \u00b1 15.1; 71% men, 80% whites, 61% ischemic cardiomyopathy) and primary (75%) or secondary prevention ICD underwent a 5\u2010minute baseline near\u2010field electrogram (NF EGM) recording. VV\u2032 alternans triplets were quantified as a percentage of three sinus VV\u2032 cycles sequences of \u201cshort\u2010long\u2010short\u201d or \u201clong\u2010short\u2010long\u201d order. Appropriate ICD shock for fast ventricular tachycardia (FVT, cycle length \u2264240 ms)\/ventricular fibrillation (VF) and composite nonarrhythmic death (pump failure death or heart transplant) served as competing outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median follow\u2010up of 2.4 years, 26 patients (4.6% per person\u2010year of follow\u2010up) developed FVT\/VF with ICD shock, and 35 (6.3% per person\u2010year of follow\u2010up) had nonarrhythmic death. In competing risk analysis, after adjustment for demographics, left ventricular ejection fraction, New York Heart Association class, cardiomyopathy type, use of class I antiarrhythmics, and diabetes, increased percentage of VV\u2032 alternans triplets (&gt;69%) was associated with nonarrhythmic death (subhazard ratio [SHR] 2.09; 95% confidence interval [CI] 1.03\u20134.23; P = 0.041), rather than with FVT\/VF (SHR 1.05; 95% CI 0.45\u20132.46; P = 0.901). Risk of nonarrhythmic death was especially high in diabetics with VV\u2032 alternans triplets in the highest quartile (SHR 3.46; 95% CI 1.41\u20138.50; P = 0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In ICD patients with structural heart disease sinus VV\u2032 alternans triplets on NF EGM is independently associated with nonarrhythmic death, rather than with FVT\/VF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12594","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T04:41:11Z","timestamp":1425962471000},"page":"547-557","source":"Crossref","is-referenced-by-count":1,"title":["VV\u2032 Alternans Triplets on Near\u2010Field ICD Intracardiac Electrogram is Associated with Mortality"],"prefix":"10.1111","volume":"38","author":[{"given":"MATHIAS","family":"BAUMERT","sequence":"first","affiliation":[{"name":"School of Electrical and Electronic Engineering The University of Adelaide  Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MUAMMAR M.","family":"KABIR","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering The University of Adelaide  Adelaide Australia"},{"name":"Knight Cardiovascular Institute Oregon Health and Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KHIDIR","family":"DALOUK","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute Oregon Health and Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHARLES A.","family":"HENRIKSON","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute Oregon Health and Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LARISA G.","family":"TERESHCHENKO","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute Oregon Health and Science University  Portland Oregon"},{"name":"Division of Cardiology Department of Medicine The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1161\/CIRCULATIONAHA.107.742155"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1016\/j.hrthm.2013.10.046"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1016\/j.cardfail.2013.04.007"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1161\/CIRCEP.113.000958"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1046\/j.1460-9592.2002.01307.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1161\/CIRCEP.108.829440"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.3389\/fphys.2013.00208"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_1","DOI":"10.1080\/01621459.1999.10474144"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1016\/j.jelectrocard.2009.07.011"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1161\/01.CIR.38.1.5"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.1016\/S0002-8703(44)90923-3"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1016\/0002-8703(48)90405-0"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1161\/01.CIR.11.2.240"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1161\/01.CIR.95.2.316"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.7326\/0003-4819-122-2-199501150-00007"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1161\/CIRCULATIONAHA.104.518449"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.1161\/01.CIR.93.10.1836"},{"doi-asserted-by":"publisher","key":"e_1_2_5_19_1","DOI":"10.1016\/S0008-6363(96)00008-9"},{"doi-asserted-by":"publisher","key":"e_1_2_5_20_1","DOI":"10.1109\/TBME.2005.857636"},{"doi-asserted-by":"publisher","key":"e_1_2_5_21_1","DOI":"10.1016\/j.jacc.2011.06.029"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.12594","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.12594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:59:36Z","timestamp":1696237176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.12594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/pace.12594"],"URL":"https:\/\/doi.org\/10.1111\/pace.12594","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}