{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:29:21Z","timestamp":1775766561935,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent clinical studies have shown conflicting results of the efficacy of renal sympathetic denervation (RSD) to mitigate hypertension. In this study, we compared electrical stimulation (ES) of autonomic nerves on the surface of the left pulmonary artery (LPA) and renal arteries (RAs) on heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP), and cardiac arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 16 pentobarbital anesthetized dogs, standard electrocardiography leads and blood pressure (BP) were continuously recorded. After a left thoracotomy, a circumferential multielectrode catheter was secured around the LPA. Atrial pacing was coupled to the ES applied around the LPA during the QRS complex to avoid ventricular excitation. Flank incisions allowed retroperitoneal expose of the RAs and the aortico\u2010renal ganglia (ARG). HR and SBP\/DBP were determined at baseline (BL) and during ES of LPA, RA, or ARG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During ES applied to the LPA, HR was unchanged compared to BL values. In four of six animals, ventricular tachyarrhythmias were induced by ES. SBP increased significantly (BL vs ES, 129\u00a0\u00b1\u00a017 mm Hg vs 163\u00a0\u00b1\u00a021 mm Hg, P\u00a0\u2264\u00a00.05). ES applied to the RAs and ARG did not affect the HR, but significantly increased SBP\/DBP (baseline: 134\u00a0\u00b1\u00a024\/96\u00a0\u00b1\u00a018 mm Hg; RAs stimulation: 157\u00a0\u00b1\u00a026\/114\u00a0\u00b1\u00a018 mm Hg; ARG stimulation: 207\u00a0\u00b1\u00a044\/147\u00a0\u00b1\u00a026 mm Hg, P\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ES of vascular autonomic nerves on LPA, RAs, and ARG significantly increased BP but without effects on HR. ES of ARG induced substantially greater hypertensive responses than ES of RAs, implying that ES of ARG may serve as a biomarker or ablation targets for RSD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12603","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T09:57:04Z","timestamp":1422871024000},"page":"825-830","source":"Crossref","is-referenced-by-count":13,"title":["Electrical Stimulation of Vascular Autonomic Nerves: Effects on Heart Rate, Blood Pressure, and Arrhythmias"],"prefix":"10.1111","volume":"38","author":[{"given":"JIAN","family":"SUN","sequence":"first","affiliation":[{"name":"Department of Cardiology Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENJAMIN J.","family":"SCHERLAG","sequence":"additional","affiliation":[{"name":"Heart Rhythm Institute, University of Oklahoma HSC  Oklahoma City 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