{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:58:08Z","timestamp":1762999088110},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Governmental Funding of Clinical Research within the Swedish National Health Service"},{"name":"Swedish Heart and Lund foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) with or without a defibrillator has a positive effect on mortality and morbidity for patients with heart failure. However, comparisons between CRT\u2010defibrillators (CRT\u2010D) and CRT\u2010pacemakers (CRT\u2010P) are relatively scarce outside the clinical trial setting. This study aimed to assess baseline characteristics in relation to long\u2010term prognosis in patients treated with CRT, and to investigate the potential benefit of CRT\u2010D versus CRT\u2010P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively collected from the medical records of all consecutive patients treated with CRT\u2010P or primary prophylactic CRT\u2010D at a large tertiary care center between 1999 and 2012. Predictors of mortality were investigated, and time\u2010dependent analysis was performed with all\u2010cause mortality as the primary end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 705 patients were included (69.6 \u00b1 10 years, 78% New York Heart Association classes III\u2013IV, left ventricular ejection fraction median 25%, 16% female, 36% CRT\u2010D). The patients were followed for a median of 59 months. Annual mortality differed between CRT\u2010D primary prophylactic and CRT\u2010P groups (5.3% and 11.8%, respectively), but when adjusted for covariates, CRT\u2010D treatment (compared to CRT\u2010P) was not associated with better long\u2010term survival. Independent predictors of survival were: age, use of loop diuretics, hemoglobin levels, and use of renin angiotensin aldosterone system blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In CRT treatment outside of the clinical trial setting, CRT\u2010D treatment was not an independent predictor of long\u2010term survival. Future research should focus on correct selection of the patients who receive enough benefit of an added defibrillator to justify CRT\u2010D implantation instead of CRT\u2010P treatment only.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12631","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T09:59:24Z","timestamp":1426759164000},"page":"758-767","source":"Crossref","is-referenced-by-count":18,"title":["Long\u2010Term Results of Cardiac Resynchronization Therapy: A Comparison between CRT\u2010Pacemakers versus Primary Prophylactic CRT\u2010Defibrillators"],"prefix":"10.1111","volume":"38","author":[{"given":"CHRISTIAN","family":"REITAN","sequence":"first","affiliation":[{"name":"Lund University, Arrhythmia Clinic Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"UZMA","family":"CHAUDHRY","sequence":"additional","affiliation":[{"name":"Lund University, Arrhythmia Clinic Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZOLTAN","family":"BAKOS","sequence":"additional","affiliation":[{"name":"Lund University, Arrhythmia Clinic Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHAN","family":"BRANDT","sequence":"additional","affiliation":[{"name":"Lund University, Arrhythmia Clinic Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINGWEI","family":"WANG","sequence":"additional","affiliation":[{"name":"Lund University, Arrhythmia Clinic Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PYOTR G.","family":"PLATONOV","sequence":"additional","affiliation":[{"name":"Lund University, Arrhythmia Clinic Skane University Hospital  Lund 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