{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:31:07Z","timestamp":1788784267778,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>According to the ACC\/AHA\/HRS guidelines, cardiac pacing is reasonable in patients with bifascicular block (BF\u2010B) and syncope when other causes have been excluded. The purpose of this study was to assess the long\u2010term outcome of patients with BF\u2010B and unexplained syncope following cardiac pacing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Between 2009 and 2015, we identified 43 consecutive patients (mean age of 78 \u00b1 12 years, 64% males) who presented with syncope and BF\u2010B and had received a pacemaker (PM). During a mean follow\u2010up period of 31 \u00b1 21 months, syncope recurred in seven patients (16%): 7% (95%\u00a0standard error [SE] \u00b1 3%) at 1 year and 18% (95%\u00a0SE \u00b1 7%) at 5 years. At univariable analysis, the only predictor of syncope recurrence was empiric pacing (P = 0.03). There were no syncope recurrences in the 12 patients who received a PM following a positive electrophysiological study (EPS) and the five patients with documentation of paroxysmal atrioventricular block (AVB) during cardiac monitoring (insertable loop recorder [ILR]), (EPS\/ILR Group, n = 17) compared to seven of 26 (27%) patients who received empiric pacing (Empiric Group, n = 26; P = 0.02). Progression to high\u2010degree AVB was documented during follow\u2010up in 16 (37%) patients: nine of 17 (53%) patients in the EPS\/ILR Group and seven of 26 (27%) patients in the Empiric Group (P = 0.11). There were no injuries reported during ILR monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have shown that syncope recurs not infrequently in patients with BF\u2010B who received pacing for syncope. Nearly one in four patients who had empiric pacing suffered syncope recurrence compared to no recurrences in patients who received a PM following a positive EPS or documentation of transient AVB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12946","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T02:43:00Z","timestamp":1472265780000},"page":"1126-1131","source":"Crossref","is-referenced-by-count":26,"title":["Long\u2010Term Outcome of Patients with Bifascicular Block and Unexplained Syncope Following Cardiac Pacing"],"prefix":"10.1111","volume":"39","author":[{"given":"MATTHEW M.","family":"KALSCHEUR","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAOLO","family":"DONATEO","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEVIN E.","family":"WENZKE","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MILENA","family":"ASTE","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIELE","family":"ODDONE","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALBERTO","family":"SOLANO","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERTO","family":"MAGGI","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCESCO","family":"CROCI","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD L.","family":"PAGE","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHELE","family":"BRIGNOLE","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmologic Centre Ospedali del Tigullio  Lavagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOHAMED H.","family":"HAMDAN","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.097837"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.6.1265"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207153070301"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90469-6"},{"key":"e_1_2_7_6_1","first-page":"e350","article-title":"American College of Cardiology\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, Society of Thoracic Surgeons. ACC\/AHA\/HRS 2008 guidelines for device\u2010based therapy of cardiac rhythm abnormalities: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC\/AHA\/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons","volume":"117","author":"Epstein AE","year":"2008","journal-title":"Circulation"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/eupc.2002.0265"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp298"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.029"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.056"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-3-302"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1988.tb05986.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.975102"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr071"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv425"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpace.12946","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.12946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:16:49Z","timestamp":1695712609000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.12946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,22]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/pace.12946"],"URL":"https:\/\/doi.org\/10.1111\/pace.12946","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,22]]}}}