{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:18:03Z","timestamp":1695799083444},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) was shown to improve heart failure (HF) prognosis. But many patients do not benefit from CRT. Optimization of left ventricular (LV) lead position to the latest activated LV area is important to increase CRT response. We aimed to detect the relationship between LV lead sensing delay and echocardiographic and electrocardiographic response to CRT treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively included 156 consecutive patients with HF diagnosis, QRS \u2265 120 ms, left bundle branch block, New York Heart Association II\u2013IV, LV ejection fraction (LVEF) &lt; 35%, and scheduled for CRT (100 male, 56 female; mean age 65.8 \u00b1 10.06 years). Echocardiographic CRT response was defined as \u226515% reduction in LV end\u2010systolic volume (LVESV). LV lead sensing delay was calculated as the time interval from the onset of surface QRS wave to the onset of depolarization wave recorded from the LV lead by using the LV pacing lead as a bipolar electrode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVESV reduction was associated with baseline QRS width (r = 0.292, P = 001), QRS narrowing (r = 0.332, P &lt; 001), and LV lead sensing delay (r = 0.454, P &lt; 001) in bivariate analysis. In logistic regression analysis, LV lead sensing delay was found to be the only independent parameter for predicting significant LVESV reduction (\u03b2 = 0.423, P &lt; 0.001). LV lead sensing delay was also found to be significantly associated with LVEF increase (r = 0.320, P &lt; 0.001) and QRS narrowing (r = 0.345, P &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LV lead sensing delay is the only independent predictor for significant reduction in LVESV and was found to be significantly associated with LVEF increase and QRS narrowing after CRT treatment. We suggest that LV lead sensing delay may be used as a marker to predict the favorable response to CRT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12963","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T12:22:51Z","timestamp":1476793371000},"page":"1317-1326","source":"Crossref","is-referenced-by-count":3,"title":["High Left Ventricular Lead Sensing Delay Predicts QRS Narrowing and Good Response to Cardiac Resynchronization Therapy"],"prefix":"10.1111","volume":"39","author":[{"given":"ONUR","family":"KAYPAKLI","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Adana Health Practices and Research Center  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEVL\u00dcT","family":"KO\u00c7","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Adana Health Practices and Research Center  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00d6KHAN","family":"G\u00d6Z\u00dcB\u00dcY\u00dcK","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Adana Health Practices and Research Center  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DURMU\u015e YILDIRAY","family":"\u015eAH\u0130N","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Adana Health Practices and Research Center  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs033"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.046"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.030"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.11.010"},{"key":"e_1_2_5_6_1","first-page":"21","article-title":"Implantation of left ventricular lead guided by electrical mapping in a heart failure patient receiving cardiac resynchronization therapy","volume":"16","author":"Liang YC","year":"2012","journal-title":"Chin J Cardiac Arrhythm"},{"key":"e_1_2_5_7_1","first-page":"196","article-title":"The feasibility and curative effect of cardiac resynchronization therapy by targeted left ventricular lead placement to the latest ventricular electrical activating site mapped in the CS branches","volume":"6","author":"Liang YC","year":"2012","journal-title":"Chin J Cardiac Pacing Electrophysiol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur250"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_2_5_10_1","first-page":"1280","article-title":"Two\u2010dimensional echocardiographic determination of left ventricular volume, systolic function, and mass. 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