{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:56Z","timestamp":1787585996665,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 #HL0070111"],"award-info":[{"award-number":["T32 #HL0070111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Automated external defibrillators can provide life\u2010saving therapies to treat ventricular fibrillation. We developed a prototype unit that can deliver a unique shock waveform produced by four independent capacitors that is delivered through two shock vectors, with the rationale of providing more robust shock pathways during emergent defibrillation. We describe the initial testing and feasibility of this unique defibrillation unit, features of which may enable downsizing of current defibrillator devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested our defibrillation unit in four large animal models (two canine and two swine) under general anesthesia. Experimental defibrillation thresholds (DFT) were obtained by delivery of a unique waveform shock pulse via a dual\u2010vector pathway with four defibrillation pads (placed across the chest). DFTs were measured and compared with those of a commercially available biphasic defibrillator (Zoll M series, Zoll Medical, Chelmsford, MA, USA) tested in two different vectors. Shocks were delivered after 10 seconds of stable ventricular fibrillation and the output characteristics and shock outcome recorded. Each defibrillation series used a step\u2010down to failure protocol to define the defibrillation threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 96 shocks were delivered during ventricular fibrillation in four large animals. In comparison to the Zoll M series, which delivered a single\u2010vector, biphasic shock, the energy required for successful defibrillation using the unique dual\u2010vector biphasic waveform did not differ significantly (P = 0.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our early findings support the feasibility of a unique external defibrillation unit using a dual\u2010vector biphasic waveform approach. This warrants further study to leverage this unique concept and work toward a miniaturized, portable shock delivery system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12979","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T06:52:48Z","timestamp":1482130368000},"page":"108-114","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of a Unique Defibrillation Unit with Dual\u2010Vector Biphasic Waveform Capabilities: Towards a Miniaturized Defibrillator"],"prefix":"10.1111","volume":"40","author":[{"given":"HIDEO","family":"OKAMURA","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER V.","family":"DESIMONE","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMMAR M.","family":"KILLU","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMILY J.","family":"GILLES","sequence":"additional","affiliation":[{"name":"Mayo Clinic Ventures Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JASON","family":"TRI","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSHINI","family":"ASIRVATHAM","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEJAE J.","family":"LADEWIG","sequence":"additional","affiliation":[{"name":"Mayo Clinic Ventures Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SCOTT H.","family":"SUDDENDORF","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOANNE M.","family":"POWERS","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTINA M.","family":"WOOD\u2010WENTZ","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER D.","family":"GRAY","sequence":"additional","affiliation":[{"name":"Employees and equity owners in CardioThrive  Walnut Creek California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DOUGLAS M.","family":"RAYMOND","sequence":"additional","affiliation":[{"name":"Employees and equity owners in CardioThrive  Walnut Creek California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHELLEY J.","family":"SAVAGE","sequence":"additional","affiliation":[{"name":"Employees and equity owners in CardioThrive  Walnut Creek California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WALTER T.","family":"SAVAGE","sequence":"additional","affiliation":[{"name":"Employees and equity owners in CardioThrive  Walnut Creek California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHARLES J.","family":"BRUCE","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAMUEL J.","family":"ASIRVATHAM","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL A.","family":"FRIEDMAN","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00128-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001034"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1832"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040566"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.109.889576"},{"key":"e_1_2_6_7_1","unstructured":"Zoll M Series service manual 9650\u20100450\u201001 Rev P. 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