{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:15:59Z","timestamp":1762506959594},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL007111"],"award-info":[{"award-number":["T32 HL007111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Echocardiographically detected patent foramen ovale (PFO) has been associated with stroke\/transient ischemic attack (TIA) in patients with cardiac implantable electronic devices (CIEDs). We sought to evaluate the relationship between echocardiographic characteristics and risk of stroke\/TIA and mortality in CIED patients with PFO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 6,086 device patients, PFO was detected in 319 patients. A baseline echocardiogram was present in 250 patients, with 186 having a follow\u2010up echocardiogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 250 patients with a baseline echocardiogram, 9.6% (n = 24) had a stroke\/TIA during mean follow\u2010up of 5.3 \u00b1 3.1 years; and 42% (n = 105) died over 7.1 \u00b1 3.7 years. Atrial septal aneurysm, prominent Eustachian valve, visible shunting across PFO, baseline or change in estimated right ventricular systolic pressure (RVSP)\/tricuspid regurgitation (TR), or maximum RVSP were not associated with postimplant stroke\/TIA (P &gt; 0.05). An exploratory multivariate analysis using time\u2010dependent Cox models showed increased hazard of death in patients with increase in TR \u22652 grades (hazard ratio [HR] 1.780, 95% confidence interval [CI] 1.447\u20132.189, P &lt; 0.0001), or increase in RVSP by &gt;10 mm Hg (HR 2.018, 95% CI 1.593\u20132.556, P &lt; 0.0001), or maximum RVSP in follow\u2010up (HR 1.432, 95% CI 1.351\u20131.516, P &lt; 0.0001). A significant increase (P &lt; 0.001) in TR was also noted during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with CIED and PFO, structural and hemodynamic echocardiographic markers did not predict future stroke\/TIA. However, a significantly higher TR or RVSP was associated with higher mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.12985","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T09:22:45Z","timestamp":1481534565000},"page":"310-322","source":"Crossref","is-referenced-by-count":2,"title":["Endocardial Device Leads in Patients with Patent Foramen Ovale: Echocardiographic Correlates of Stroke\/TIA and Mortality"],"prefix":"10.1111","volume":"40","author":[{"given":"SHIVA P.","family":"PONAMGI","sequence":"first","affiliation":[{"name":"Division of Hospital Internal Medicine Mayo Clinic Health System  Austin Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VAIBHAV R.","family":"VAIDYA","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER 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