{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T08:47:05Z","timestamp":1782031625729,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006279","name":"St. Jude Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Left ventricular end\u2010systolic volume (LVESV) changes at 6 months and clinical status are useful for assessing responses to cardiac resynchronization therapy (CRT). Regression of the LVESV following CRT has not been described beyond 6 months. This study aimed to assess the proportion, predictors, and clinical outcomes of responders whose LVESVs had regressed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 104 consecutive CRT patients. A responder was defined as a patient with a relative reduction in the LVESV \u226515% at 6 months after CRT. Fifty\u2010six responders participated in this study. A transient responder was defined as a responder without a relative reduction in the LVESV \u226515% at 2 years after CRT or who died of cardiac events during the 24\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 56 responders, 16 (29%) were transient responders. Multivariable logistic regression analysis showed that chronic atrial fibrillation (odds ratio [OR] = 19.2, 95% confidence interval [CI] [1.93, 190], P = 0.012) and amiodarone usage (OR = 60.9, 95% CI [4.18, 886], P = 0.003) were independent predictors of transient responses. Hospitalizations for heart failure were significantly higher among the transient responders than among the lasting responders during a mean follow\u2010up period of 7.6 years (log\u2010rank P &lt; 0.001), and all\u2010cause mortality tended to be higher among the transient responders (log\u2010rank P = 0.093).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One\u2010third of the responders were transient responders at 2 years after CRT, and their long\u2010term prognoses were poor. Careful attention should be paid to maintain the reduction in LVESV especially in patients with chronic AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13023","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:24:51Z","timestamp":1484321091000},"page":"301-309","source":"Crossref","is-referenced-by-count":8,"title":["Predictors and Clinical Outcomes of Transient Responders to Cardiac Resynchronization Therapy"],"prefix":"10.1111","volume":"40","author":[{"given":"HIROTOSHI","family":"ICHIBORI","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KOJI","family":"FUKUZAWA","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Section of 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