{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T15:02:56Z","timestamp":1718722976023},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC96\u20102628\u2010B\u2010038\u2010012\u2010MY3, NSC97\u20102314\u2010B\u2010038\u2010030\u2010MY3, NSC98\u20102314\u2010B\u2010010\u2010031\u2010MY3"],"award-info":[{"award-number":["NSC96\u20102628\u2010B\u2010038\u2010012\u2010MY3, NSC97\u20102314\u2010B\u2010038\u2010030\u2010MY3, NSC98\u20102314\u2010B\u2010010\u2010031\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["102TMU\u2010WFH\u201009, 104TMU\u2010WFH\u201016, 104\u2010wf\u2010eva\u201006, 105swf02"],"award-info":[{"award-number":["102TMU\u2010WFH\u201009, 104TMU\u2010WFH\u201016, 104\u2010wf\u2010eva\u201006, 105swf02"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Autonomic nervous activity plays a critical role in the genesis of paroxysmal atrial fibrillation (AF, PAF). However, the role of autonomic nervous activity on AF termination has not been elucidated. Heart rate variability (HRV) is widely used to evaluate autonomic nervous activity in humans. The purpose of this study was to assess whether autonomic nervous activity assessed by HRV contributes to AF termination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electrocardiograms (ECGs) and HRV were studied in patients with termination of sustained (&gt;30 s) PAF by 24\u2010hour ambulatory Holter monitoring. The 20\u2010minute interval after termination of AF was divided into four segments of 5 minutes each, and a frequency analysis was applied to each 5\u2010minute segment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 52 AF episodes, the ultra\u2010low\u2010frequency power, very\u2010low\u2010frequency power, low\u2010frequency power (LF), high\u2010frequency power (HF), and total power significantly decreased with time after episodes of AF termination. The LF\/HF (L\/H) ratio, normalized LF (LFnu), and normalized HF (HFnu) significantly changed after AF termination. Eighteen (35%) episodes had decreased LFnu and increased HFnu (sympathetic withdrawal and vagal activation), which had slower average AF ventricular responses (92\u00a0\u00b1 16 beats\/min vs 105 \u00b1 24 beats\/min, P &lt; 0.05) than the AF termination episodes (n = 34, 65%) with increased LFnu and decreased HFnu (sympathetic activation and vagal withdrawal). Moreover, older patients (aged &gt;65 years) had a higher incidence (n = 27, 75%) of AF termination with increased LFnu and decreased HFnu than did younger patients (aged \u226465 years, n = 7, 44%, P &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Autonomic changes critically regulate termination of PAF, which is modulated by aging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.13045","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T09:56:42Z","timestamp":1486634202000},"page":"401-408","source":"Crossref","is-referenced-by-count":5,"title":["Modulation of Autonomic Nervous Activity in the Termination of Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"40","author":[{"given":"JEN\u2010HUNG","family":"HUANG","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUNG\u2010KUO","family":"LIN","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MING\u2010HSIUNG","family":"HSIEH","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIH\u2010ANN","family":"CHEN","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiovascular Research Center Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WAN\u2010CHUN","family":"CHIU","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, College of Nutrition Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YI\u2010JEN","family":"CHEN","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.08.042"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3282f26d07"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00305-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03503.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.06.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01159.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.633560"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00592.x"},{"key":"e_1_2_7_12_1","first-page":"354","article-title":"Standards of measurement, physiological interpretation, and clinical use. 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